ArticleJournal of clinical microbiology2010
Evidence for a second genomic island conferring multidrug resistance in a clonal group of strains of Salmonella enterica serovar Typhimurium and its monophasic variant circulating in Italy, Denmark, and the United Kingdom.
Article in Journal of clinical microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- GWAS and Machine Learning Screening of Genomic Determinants Underlying Host Adaptation in Swine and ChickenMicroorganisms · 2026Article
- Antibiotic susceptibility pattern and resistance genes in Salmonella strains isolated from cattle.BMC veterinary research · 2025Article
- Monophasic Variant ofMicroorganisms · 2023Article
- Antibiotic Resistance in Selected Emerging Bacterial Foodborne Pathogens-An Issue of Concern?Antibiotics (Basel, Switzerland) · 2023Review
- Phenotypic and genotypic antimicrobial resistance correlation and plasmid characterization inFrontiers in public health · 2023Article
- Prevalence and antimicrobial resistance profile inItalian journal of food safety · 2022Article
- Antibiotic Resistance ofAntibiotics (Basel, Switzerland) · 2022Review
- Sequence Analyses and Phenotypic Characterization Revealed Multidrug Resistant Gene Insertions in the Genomic Region Encompassing Phase 2 Flagellin EncodingFrontiers in microbiology · 2021Article
- Article
- Characterization of Salmonella Typhimurium and its monophasic variant 1,4, [5],12:i:- isolated from different sources.Folia microbiologica · 2019Article
- Non-typhoidalPathogens (Basel, Switzerland) · 2019Review
- Characterization of non-typhoidalItalian journal of food safety · 2018Article
- Non-typhoidalBMJ open · 2017Article
- ECDC/EFSA/EMA second joint report on the integrated analysis of the consumption of antimicrobial agents and occurrence of antimicrobial resistance in bacteria from humans and food-producing animals: Joint Interagency Antimicrobial Consumption and Resistance Analysis (JIACRA) Report.EFSA journal. European Food Safety Authority · 2017Article
- Salmonella in the pork production chain and its impact on human health in the European Union.Epidemiology and infection · 2017Review
- Diverse distribution of Toxin-Antitoxin II systems in Salmonella enterica serovars.Scientific reports · 2016Article
- Occurrence and antimicrobial resistance of Salmonella strains from food of animal origin in southern Italy.Folia microbiologica · 2016Article
- Horizontal Acquisition of a Multidrug-Resistance Module (R-type ASSuT) Is Responsible for the Monophasic Phenotype in a Widespread Clone of Salmonella Serovar 4,[5],12:i:.Frontiers in microbiology · 2016Article
- Outbreak of uncommon O4 non-agglutinating Salmonella typhimurium linked to minced pork, Saxony-Anhalt, Germany, January to April 2013.PloS one · 2015Article
- Chromosome-mediated multidrug resistance in Salmonella enterica serovar Typhi.Antimicrobial agents and chemotherapy · 2015Article
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Authors and funding
9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
During the 2000s, a new clonal group with resistances to ampicillin, streptomycin, sulfonamides, and tetracycline (ASSuT) emerged in Italy among strains of Salmonella enterica serovar Typhimurium and its monophasic variant, Salmonella enterica subspecies enterica serovar 4,[5],12:i:-. The PulseNet Europe database allowed us to identify ASSuT strains of both S. Typhimurium and its monophasic variant, isolated in Denmark and the United Kingdom, with the same or very closely related pulsed-field gel electrophoresis (PFGE) patterns as the Italian strains, suggesting that the ASSuT clonal group is circulating in different European countries. With the aim of analyzing the molecular basis of antibiotic resistance, resistance genes were identified and their localization was investigated in 66 ASSuT strains and, as controls, in 11 strains with different resistance patterns and PFGE profiles, belonging both to S. Typhimurium and to its monophasic variant, isolated from humans in Italy, Denmark, and the United Kingdom. All the ASSuT strains were positive for the following resistance genes: bla(TEM-1), strA-strB, sul2, and tet(B). A localization experiment demonstrated that the ASSuT resistance genes are chromosomally located. This study confirms that a multidrug-resistant clonal group, ASSuT, of S. Typhimurium and its monophasic variant has emerged and is circulating in Italy, Denmark, and the United Kingdom. Moreover, the results of this work demonstrate that the multidrug resistance in this clonal group of Salmonella strains is conferred by a new genomic island.
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