ArticleSchizophrenia bulletin2011
Verbal and visual memory impairments among young offspring and healthy adult relatives of patients with schizophrenia and bipolar disorder: selective generational patterns indicate different developmental trajectories.
Article in Schizophrenia bulletin, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 64 citations in OpenAlex.
- Bipolar disorders and schizophrenia: discrete disorders?Frontiers in psychiatry · 2024Review
- Cognitive reserve and its correlates in child and adolescent offspring of patients diagnosed with schizophrenia or bipolar disorder.European child & adolescent psychiatry · 2023Article
- Childhood Trauma May Increase Risk of Psychosis and Mood Disorder in Genetically High-risk Children and Adolescents by Enhancing the Accumulation of Risk Indicators.Schizophrenia bulletin open · 2022Article
- Genetic EffectsNeuropsychiatric disease and treatment · 2020Article
- Mapping the Consequences of Impaired Synaptic Plasticity in Schizophrenia through Development: An Integrative Model for Diverse Clinical Features.Trends in cognitive sciences · 2017Review
- The Lausanne-Geneva cohort study of offspring of parents with mood disorders: methodology, findings, current sample characteristics, and perspectives.Social psychiatry and psychiatric epidemiology · 2017Article
- Opposite Cannabis-Cognition Associations in Psychotic Patients Depending on Family History.PloS one · 2016Article
- A feasibility study of a new computerised cognitive remediation for young adults with schizophrenia.Neuropsychological rehabilitation · 2016Article
- Altered Cortico-Striatal Connectivity in Offspring of Schizophrenia Patients Relative to Offspring of Bipolar Patients and Controls.PloS one · 2016Article
- Childhood abuse and neglect may induce deficits in cognitive precursors of psychosis in high-risk children.Journal of psychiatry & neuroscience : JPN · 2015Article
- FitzPatrick Lecture: King George III and the porphyria myth - causes, consequences and re-evaluation of his mental illness with computer diagnostics.Clinical medicine (London, England) · 2015Article
- The relationship between sleep-wake cycle and cognitive functioning in young people with affective disorders.PloS one · 2015Article
- Cluster analysis of cognitive deficits may mark heterogeneity in schizophrenia in terms of outcome and response to treatment.European archives of psychiatry and clinical neuroscience · 2014Article
- Extension of the generalized disequilibrium test to polytomous phenotypes and two-locus models.Frontiers in genetics · 2014Article
- Evaluating differential developmental trajectories to adolescent-onset mood and psychotic disorders.BMC psychiatry · 2013Article
- Article
- Brain activation patterns during visual episodic memory processing among first-degree relatives of schizophrenia subjects.NeuroImage · 2012Article
- Article
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveMemory deficits have been shown in patients affected by schizophrenia (SZ) and bipolar (BP)/mood disorder. We recently reported that young high-risk offspring of an affected parent were impaired in both verbal episodic memory (VEM) and visual episodic memory (VisEM). Understanding better the trajectory of memory impairments from childhood to adult clinical status in risk populations is crucial for early detection and prevention. In multigenerational families densely affected by SZ or BP, our aim was to compare the memory impairments observed in young nonaffected offspring with memory functioning in nonaffected adult relatives and patients.
methodsFor 20 years, we followed up numerous kindreds in the Eastern Québec population. After having characterized the Diagnostic and Statistical Manual of Mental Disorders phenotypes, we assessed cognition (N = 381) in 3 subsamples in these kindreds and in controls: 60 young offspring of a parent affected by SZ or BP, and in the adult generations, 92 nonaffected adult relatives and 40 patients affected by SZ or BP. VEM was assessed with the California Verbal Learning Test and VisEM with the Rey figures.
resultsThe VEM deficits observed in the offspring were also found in adult relatives and patients. In contrast, the VisEM impairments observed in the young offspring were present only in patients, not in the adult relatives.
conclusionImplications for prevention and genetic mechanisms can be drawn from the observation that VEM and VisEM would show distinct generational trajectories and that the trajectory associated with VisEM may offer a better potential than VEM to predict future risk of developing the disease.
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