ArticleThe Journal of clinical endocrinology and metabolism2010
Frailty, serum androgens, and the CAG repeat polymorphism: results from the Massachusetts Male Aging Study.
Article in The Journal of clinical endocrinology and metabolism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed.
- Androgen receptor gene polymorphism and biological age markers in men.Scientific reports · 2025Article
- Physical frailty is related to oxidative stress through thiol/disulfide homeostasis parameters.European geriatric medicine · 2024Article
- Androgen Receptor CAG Repeat Length as a Risk Factor of Late-Onset Hypogonadism in a Korean Male Population.Sexual medicine · 2018Article
- Positive Correlation between Androgen Receptor CAG Repeat Length and Metabolic Syndrome in a Korean Male Population.The world journal of men's health · 2018Article
- Estrogens and Androgens in Skeletal Physiology and Pathophysiology.Physiological reviews · 2017Review
- Repeat polymorphisms in ESR2 and AR and colorectal cancer risk and prognosis: results from a German population-based case-control study.BMC cancer · 2014Article
- CAGn repeat of the androgen receptor is linked to proopiomelanocortin promoter methylation-relevance for craving of male alcohol-dependent patients?Psychopharmacology · 2014Article
- A preliminary case study of androgen receptor gene polymorphism association with impulsivity in women with alcoholism.Advances in genomics and genetics · 2014Article
- Measures of frailty in population-based studies: an overview.BMC geriatrics · 2013Review
- Hormone replacement therapy and physical function in healthy older men. Time to talk hormones?Endocrine reviews · 2012Review
- Frailty: diagnosis and management.The journal of nutrition, health & aging · 2011Article
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7 authors.
Funding
Abstract
contextThe CAG repeat polymorphism in the androgen receptor, denoted (CAG)n, is thought to (inversely) index androgen sensitivity. We hypothesized that (CAG)n would exhibit a modifying influence on the association between circulating total and calculated free testosterone (TT and FT) and physical frailty in aging men.
objectiveThe objective of the study was to establish the influence of (CAG)n on the relation between circulating TT, FT, LH, SHBG, and frailty.
designThis was a prospective cohort study of health and endocrine functioning in randomly selected men, with a baseline (T1: 1987-89) and two follow-up (T2: 1995-1997; T3: 2002-2004) visits.
settingThis was an observational study of men residing in greater Boston, MA.
participantsA total of 624 subjects aged 50-86 yr were retained.
main outcome measuresThe frailty phenotype was measured at T3. Components included weight loss, exhaustion, low physical activity, weakness, and slowness. Subjects exhibiting two of these five components were considered to be in an intermediate state, and those exhibiting three or more were considered frail.
results(CAG)n was positively associated with TT and FT. Multivariable regression analyses revealed no influence of CAG on longitudinal within-subject changes in hormone levels or cross-sectional (T3) associations between hormone concentrations and the prevalence of intermediate frailty or frailty. Models incorporating subjects' history of hormone decline produced similar negative results.
conclusionsThis population-based study does not support the hypothesis that interindividual differences in (CAG)n can account for a lack of association between circulating androgens and the frailty phenotype. Longitudinal analyses are needed to confirm these conclusions.
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