ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Presynaptic and postsynaptic mechanisms of synaptic plasticity and metaplasticity during intermediate-term memory formation in Aplysia.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 59 citations in OpenAlex.
- Inhibition of Rho-kinase by fasudil contributes to the modulation of the synaptic plasticity response in the rat hippocampus.Pflugers Archiv : European journal of physiology · 2025Article
- UNC-43/CaMKII-triggered anterograde signals recruit GABANature communications · 2023Article
- The contributions and mechanisms of changes in excitability during simple forms of learning in Aplysia.Neurobiology of learning and memory · 2019Article
- Successful and unsuccessful attempts to swallow in a reducedLearning & memory (Cold Spring Harbor, N.Y.) · 2019Article
- Intermediate-term memory inLearning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Autocrine signaling by anProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Anterograde and retrograde signaling by anProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Metaplasticity at the addicted tetrapartite synapse: A common denominator of drug induced adaptations and potential treatment target for addiction.Neurobiology of learning and memory · 2018Review
- Selective Erasure of Distinct Forms of Long-Term Synaptic Plasticity Underlying Different Forms of Memory in the Same Postsynaptic Neuron.Current biology : CB · 2017Article
- Long-term habituation of the C-start escape response in zebrafish larvae.Neurobiology of learning and memory · 2016Article
- Hyperpolarization-activated, cyclic nucleotide-gated cation channels in Aplysia: Contribution to classical conditioning.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- The vertical lobe of cephalopods: an attractive brain structure for understanding the evolution of advanced learning and memory systems.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2015Review
- Nonassociative learning in invertebrates.Cold Spring Harbor perspectives in biology · 2015Review
- Decline in the Recovery from Synaptic Depression in Heavier Aplysia Results from Decreased Serotonin-Induced Novel PKC Activation.PloS one · 2015Article
- Contribution of PKC to the maintenance of 5-HT-induced short-term facilitation at sensorimotor synapses of Aplysia.Journal of neurophysiology · 2014Article
- Bio-orthogonal labeling as a tool to visualize and identify newly synthesized proteins in Caenorhabditis elegans.Nature protocols · 2014Article
- PKC-mediated GABAergic enhancement of dopaminergic responses: implication for short-term potentiation at a dual-transmitter synapse.Journal of neurophysiology · 2014Article
- Roles of calcium/calmodulin-dependent kinase II in long-term memory formation in crickets.PloS one · 2014Article
- Concepts of scientific integrative medicine applied to the physiology and pathophysiology of catecholamine systems.Comprehensive Physiology · 2013Review
- Possible contributions of a novel form of synaptic plasticity in Aplysia to reward, memory, and their dysfunctions in mammalian brain.Learning & memory (Cold Spring Harbor, N.Y.) · 2013Review
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Synaptic plasticity and learning involve different mechanisms depending on the following: (1) the stage of plasticity and (2) the history of plasticity, or metaplasticity. However, little is known about how these two factors are related. We have addressed that question by examining mechanisms of synaptic plasticity during short-term and intermediate-term behavioral sensitization and dishabituation in a semi-intact preparation of the Aplysia siphon-withdrawal reflex. Dishabituation differs from sensitization in that it is preceded by habituation, and is thus a paradigm for metaplasticity. We find that whereas facilitation during short-term sensitization by one tail shock involves presynaptic covalent modifications by protein kinase A (PKA) and CamKII, facilitation during intermediate-term sensitization by four shocks involves both presynaptic (PKA, CaMKII) and postsynaptic (Ca(2+), CaMKII) covalent modifications, as well as both presynaptic and postsynaptic protein synthesis. The facilitation also involves presynaptic spike broadening 2.5 min after either one or four shocks, but not at later times. Dishabituation by four shocks differs from sensitization in several ways. First, it does not involve PKA or CaMKII, but rather involves presynaptic PKC. In addition, unlike sensitization with the same shock, dishabituation by four shocks does not involve protein synthesis or presynaptic spike broadening, and it also does not involve postsynaptic Ca(2+). These results demonstrate that not only the mechanisms but also the site of plasticity depend on both the stage of plasticity and metaplasticity during memory formation.
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Registered trials
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