ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Astrocytes impose postburst depression of release probability at hippocampal glutamate synapses.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Astrocytic Endocannabinoids Mediate Hippocampal Transient Heterosynaptic Depression.Neurochemical research · 2020Article
- Versatile control of synaptic circuits by astrocytes: where, when and how?Nature reviews. Neuroscience · 2018Review
- Does rapid and physiological astrocyte-neuron signalling amplify epileptic activity?The Journal of physiology · 2017Review
- Optogenetic and Chemogenetic Approaches for Studying Astrocytes and Gliotransmitters.Experimental neurobiology · 2016Review
- Enteric Glial Cells: A New Frontier in Neurogastroenterology and Clinical Target for Inflammatory Bowel Diseases.Inflammatory bowel diseases · 2016Review
- Postactivation depression of the Ia EPSP in motoneurons is reduced in both the G127X SOD1 model of amyotrophic lateral sclerosis and in aged mice.Journal of neurophysiology · 2015Article
- Bursting reverberation as a multiscale neuronal network process driven by synaptic depression-facilitation.PloS one · 2015Article
- Astroglial calcium signaling displays short-term plasticity and adjusts synaptic efficacy.Frontiers in cellular neuroscience · 2015Article
- Article
- Data and model tango to aid the understanding of astrocyte-neuron signaling.Frontiers in computational neuroscience · 2014Article
- Astrocytes release D-serine by a large vesicle.Neuroscience · 2013Article
- Upregulation of transmitter release probability improves a conversion of synaptic analogue signals into neuronal digital spikes.Molecular brain · 2012Article
- A mathematical model of the tripartite synapse: astrocyte-induced synaptic plasticity.Journal of biological physics · 2012Article
- Optogenetic activation of LiGluR-expressing astrocytes evokes anion channel-mediated glutamate release.The Journal of physiology · 2012Article
- Computational quest for understanding the role of astrocyte signaling in synaptic transmission and plasticity.Frontiers in computational neuroscience · 2012Article
- A tale of two stories: astrocyte regulation of synaptic depression and facilitation.PLoS computational biology · 2011Article
- Astrocytes as regulators of synaptic function: a quest for the Ca2+ master key.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2011Review
- Astrocyte-mediated short-term synaptic depression in the rat hippocampal CA1 area: two modes of decreasing release probability.BMC neuroscience · 2011Article
- Astrocytes control GABAergic inhibition of neurons in the mouse barrel cortex.The Journal of physiology · 2011Article
- A tripartite synapse model in Drosophila.PloS one · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many neurons typically fire action potentials in brief, high-frequency bursts with specific consequences for their synaptic output. Here we have examined short-term plasticity engaged during burst activation using electrophysiological recordings in acute rat hippocampal slices. We show that CA3-CA1 glutamate synapses exhibit a prominent depression of presynaptic release probability for approximately 1 s after such a burst. This postburst depression exhibits a distinct cooperativity threshold, is abolished by inhibiting astrocyte metabolism and astrocyte calcium signaling, and is not operational in the developing hippocampus. Our results suggest that astrocytes are actively involved in short-term synaptic depression, shaping synaptic activity during behaviorally relevant neural activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.