ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
High-frequency network activity, global increase in neuronal activity, and synchrony expansion precede epileptic seizures in vitro.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed, 157 citations in OpenAlex.
- Nonlinear dynamics and multiscale mechanisms of deep brain stimulation.Frontiers in neuroscience · 2026Review
- Short-Term Modulation of Epileptic Network with Low-Frequency Thalamic Stimulation.medRxiv : the preprint server for health sciences · 2025Article
- Pathophysiological levels of extracellular calcium and potassium induce seizure-like discharges: identification of synaptic and nonsynaptic components.Journal of neurophysiology · 2025Article
- Virtual epilepsy patient cohort: Generation and evaluation.PLoS computational biology · 2025Article
- Increased coherence predicts medical refractoriness in patients with temporal lobe epilepsy on monotherapy.Scientific reports · 2024Article
- Networks through the lens of high-frequency oscillations.Frontiers in network physiology · 2024Review
- Propagation of transient explosive synchronization in a mesoscale mouse brain network model of epilepsy.Network neuroscience (Cambridge, Mass.) · 2024Article
- Isolation of the murine Glut1 deficient thalamocortical circuit: wavelet characterization and reverse glucose dependence of low and gamma frequency oscillations.Frontiers in neuroscience · 2023Article
- Timing differences between HFOs and interictal epileptiform discharges generated in vitro by different mechanisms in rat hippocampal slices: A novel approach.Epilepsia open · 2022Article
- Cellular, molecular, and therapeutic characterization of pilocarpine-induced temporal lobe epilepsy.Scientific reports · 2021Article
- ATR regulates neuronal activity by modulating presynaptic firing.Nature communications · 2021Article
- Engulfed by Glia: Glial Pruning in Development, Function, and Injury across Species.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- Characterizing Hippocampal Oscillatory Signatures Underlying Seizures in Temporal Lobe Epilepsy.Frontiers in behavioral neuroscience · 2021Review
- The Effect of Anti-seizure Medications on the Propagation of Epileptic Activity: A Review.Frontiers in neurology · 2021Review
- Article
- Changes of Ictal-Onset Epileptic Network Synchronicity in Childhood Absence Epilepsy: A Magnetoencephalography Study.Frontiers in neurology · 2020Article
- Spectral organization of focal seizures within the thalamotemporal network.Annals of clinical and translational neurology · 2019Article
- Redaction of false high frequency oscillations due to muscle artifact improves specificity to epileptic tissue.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2019Article
- Uncovering functional signature in neural systems via random matrix theory.PLoS computational biology · 2019Article
- Quantum-like behavior without quantum physics II. A quantum-like model of neural network dynamics.Journal of biological physics · 2018Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
How seizures start is a major question in epilepsy research. Preictal EEG changes occur in both human patients and animal models, but their underlying mechanisms and relationship with seizure initiation remain unknown. Here we demonstrate the existence, in the hippocampal CA1 region, of a preictal state characterized by the progressive and global increase in neuronal activity associated with a widespread buildup of low-amplitude high-frequency activity (HFA) (>100 Hz) and reduction in system complexity. HFA is generated by the firing of neurons, mainly pyramidal cells, at much lower frequencies. Individual cycles of HFA are generated by the near-synchronous (within approximately 5 ms) firing of small numbers of pyramidal cells. The presence of HFA in the low-calcium model implicates nonsynaptic synchronization; the presence of very similar HFA in the high-potassium model shows that it does not depend on an absence of synaptic transmission. Immediately before seizure onset, CA1 is in a state of high sensitivity in which weak depolarizing or synchronizing perturbations can trigger seizures. Transition to seizure is characterized by a rapid expansion and fusion of the neuronal populations responsible for HFA, associated with a progressive slowing of HFA, leading to a single, massive, hypersynchronous cluster generating the high-amplitude low-frequency activity of the seizure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.