ArticleThe American journal of clinical nutrition2010
Total mortality risk in relation to use of less-common dietary supplements.
Article in The American journal of clinical nutrition, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Safety and Efficacy of Glucosamine and/or Chondroitin in Humans: A Systematic Review.Nutrients · 2025Pooled it
- Impact of Glucosamine Supplementation on Gut Health.Nutrients · 2021Trial
- Trial
- Glucosamine-containing supplement improves locomotor functions in subjects with knee pain: a randomized, double-blind, placebo-controlled study.Clinical interventions in aging · 2015Trial
- The association between postdiagnosis dietary supplement use and total mortality differs by diet quality among older female cancer survivors.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2014Trial
- Osteoarthritis as a marker and potential contributor to cardiovascular risk: a glycocalyx-cartilage axis hypothesis.Frontiers in cardiovascular medicine · 2026Article
- Calorie restriction mimetics against aging and inflammation.Biogerontology · 2025Review
- Calorie restriction mimetic drugs could favorably influence gut microbiota leading to lifespan extension.GeroScience · 2023Review
- Glucosamine and Chondroitin Use and Mortality Among Adults in the United States from 1999 to 2014.Journal of integrative and complementary medicine · 2023Article
- Neuroprotective and Proneurogenic Effects of Glucosamine in an Internal Carotid Artery Occlusion Model of Ischemia.Neuromolecular medicine · 2022Article
- Antiaging agents: safe interventions to slow aging and healthy life span extension.Natural products and bioprospecting · 2022Review
- Risk of ischaemic stroke among new users of glucosamine and chondroitin sulphate: a nested case-control study.Therapeutic advances in musculoskeletal disease · 2022Article
- Glycolytic inhibition: an effective strategy for developing calorie restriction mimetics.GeroScience · 2021Review
- Drug Screening Implicates Chondroitin Sulfate as a Potential Longevity Pill.Frontiers in aging · 2021Review
- Caloric Restriction Mimetics in Nutrition and Clinical Trials.Frontiers in nutrition · 2021Review
- Identification of longevity compounds with minimized probabilities of side effects.Biogerontology · 2020Article
- Azithromycin and glucosamine may amplify the type 1 interferon response to RNA viruses in a complementary fashion.Immunology letters · 2020Review
- Plant and fungal products that extend lifespan inMicrobial cell (Graz, Austria) · 2020Review
- Associations of regular glucosamine use with all-cause and cause-specific mortality: a large prospective cohort study.Annals of the rheumatic diseases · 2020Article
- Association of habitual glucosamine use with risk of cardiovascular disease: prospective study in UK Biobank.BMJ (Clinical research ed.) · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundDietary supplement use is common in older US adults; however, data on health risks and benefits are lacking for a number of supplements.
objectiveWe evaluated whether 10-y average intakes of 13 vitamin and mineral supplements and glucosamine, chondroitin, saw palmetto, Ginko biloba, garlic, fish-oil, and fiber supplements were associated with total mortality.
designWe conducted a prospective cohort study of Washington State residents aged 50-76 y during 2000-2002. Participants (n = 77,719) were followed for mortality for an average of 5 y.
resultsA total of 3577 deaths occurred during 387,801 person-years of follow-up. None of the vitamin or mineral 10-y average intakes were associated with total mortality. Among the nonvitamin-nonmineral supplements, only glucosamine and chondroitin were associated with total mortality. The hazard ratio (HR) when persons with a high intake of supplements (> or =4 d/wk for > or =3 y) were compared with nonusers was 0.83 (95% CI: 0.72, 0.97; P for trend = 0.009) for glucosamine and 0.83 (95% CI: 0.69, 1.00; P for trend = 0.011) for chondroitin. There was also a suggestion of a decreased risk of total mortality associated with a high intake of fish-oil supplements (HR: 0.83; 95% CI: 0.70, 1.00), but the test for trend was not statistically significant.
conclusionsFor most of the supplements we examined, there was no association with total mortality. Use of glucosamine and use of chondroitin were each associated with decreased total mortality.
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