ArticleJournal of lipid research2010
Dynamic simulation of cardiolipin remodeling: greasing the wheels for an interpretative approach to lipidomics.
Article in Journal of lipid research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed.
- Serum Lipidome as a Predictor of Significant Liver Fibrosis in Patients with Severe Obesity Undergoing Bariatric Surgery.Obesity surgery · 2026Article
- SOX9 Overexpression Ameliorates Metabolic Dysfunction-associated Steatohepatitis Through Activation of the AMPK Pathway.Journal of clinical and translational hepatology · 2025Article
- Mass Spectrometry Imaging Reveals Abnormalities in Cardiolipin Composition and Distribution in Astrocytoma Tumor Tissues.Cancers · 2023Article
- Effects of Sustained Hyperglycemia on Skeletal Muscle Lipids in Healthy Subjects.The Journal of clinical endocrinology and metabolism · 2022Article
- Review
- The foundations and development of lipidomics.Journal of lipid research · 2022Review
- Overview of Lipidomic Analysis of Triglyceride Molecular Species in Biological Lipid Extracts.Journal of agricultural and food chemistry · 2021Article
- Coupling Machine Learning and Lipidomics as a Tool to Investigate Metabolic Dysfunction-Associated Fatty Liver Disease. A General Overview.Biomolecules · 2021Review
- Chronic stress and antidepressant treatment alter purine metabolism and beta oxidation within mouse brain and serum.Scientific reports · 2020Article
- Skeletal Muscle Energetics and Mitochondrial Function Are Impaired Following 10 Days of Bed Rest in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Older adults with sarcopenia have distinct skeletal muscle phosphodiester, phosphocreatine, and phospholipid profiles.Aging cell · 2020Article
- Cold-Activated Lipid Dynamics in Adipose Tissue Highlights a Role for Cardiolipin in Thermogenic Metabolism.Cell reports · 2018Article
- Lipidomics for precision medicine and metabolism: A personal view.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2017Review
- Lipidomic Adaptations in White and Brown Adipose Tissue in Response to Exercise Demonstrate Molecular Species-Specific Remodeling.Cell reports · 2017Article
- Lipidomics for studying metabolism.Nature reviews. Endocrinology · 2016Review
- Lipidomics: Techniques, Applications, and Outcomes Related to Biomedical Sciences.Trends in biochemical sciences · 2016Review
- Monoacylglycerol Analysis Using MS/MS(ALL) Quadruple Time of Flight Mass Spectrometry.Metabolites · 2016Article
- Article
- Novel advances in shotgun lipidomics for biology and medicine.Progress in lipid research · 2016Review
- High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources.Journal of extracellular vesicles · 2016Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Cardiolipin is a class of mitochondrial specific phospholipid, which is intricately involved in mitochondrial functionality. Differences in cardiolipin species exist in a variety of tissues and diseases. It has been demonstrated that the cardiolipin profile is a key modulator of the functions of many mitochondrial proteins. However, the chemical mechanism(s) leading to normal and/or pathological distribution of cardiolipin species remain elusive. Herein, we describe a novel approach for investigating the molecular mechanism of cardiolipin remodeling through a dynamic simulation. This approach applied data from shotgun lipidomic analyses of the heart, liver, brain, and lung mitochondrial lipidomes to model cardiolipin remodeling, including relative content, regiospecificity, and isomeric composition of cardiolipin species. Generated cardiolipin profiles were nearly identical to those determined by shotgun lipidomics. Importantly, the simulated isomeric compositions of cardiolipin species were further substantiated through product ion analysis. Finally, unique enzymatic activities involved in cardiolipin remodeling were assessed from the parameters used in the dynamic simulation of cardiolipin profiles. Collectively, we described, verified, and demonstrated a novel approach by integrating both lipidomic analysis and dynamic simulation to study cardiolipin biology. We believe this study provides a foundation to investigate cardiolipin metabolism and bioenergetic homeostasis in normal and disease states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.