ArticleBiophysical journal2010
Force transduction by the microtubule-bound Dam1 ring.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Mechanical Mechanisms of Chromosome Segregation.Cells · 2021Review
- Electrostatic forces drive poleward chromosome motions at kinetochores.Cell division · 2016Article
- Statistical mechanics provides novel insights into microtubule stability and mechanism of shrinkage.PLoS computational biology · 2015Article
- Accurate phosphoregulation of kinetochore-microtubule affinity requires unconstrained molecular interactions.The Journal of cell biology · 2014Article
- Highly Transient Molecular Interactions Underlie the Stability of Kinetochore-Microtubule Attachment During Cell Division.Cellular and molecular bioengineering · 2013Article
- Growth and shortening of microtubules: a two-state model approach.The Journal of biological chemistry · 2011Article
- Filament depolymerization can explain chromosome pulling during bacterial mitosis.PLoS computational biology · 2011Article
- Ringing the changes: emerging roles for DASH at the kinetochore-microtubule Interface.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2011Review
- Kinetochores' gripping feat: conformational wave or biased diffusion?Trends in cell biology · 2011Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The coupling between the depolymerization of microtubules (MTs) and the motion of the Dam1 ring complex is now thought to play an important role in the generation of forces during mitosis. Our current understanding of this motion is based on a number of detailed computational models. Although these models realize possible mechanisms for force transduction, they can be extended by variation of any of a large number of poorly measured parameters and there is no clear strategy for determining how they might be distinguished experimentally. Here we seek to identify and analyze two distinct mechanisms present in the computational models. In the first, the splayed protofilaments at the end of the depolymerizing MT physically prevent the Dam1 ring from falling off the end, and in the other, an attractive binding secures the ring to the microtubule. Based on this analysis, we discuss how to distinguish between competing models that seek to explain how the Dam1 ring stays on the MT. We propose novel experimental approaches that could resolve these models for the first time, either by changing the diffusion constant of the Dam1 ring (e.g., by tethering a long polymer to it) or by using a time-varying load.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.