ArticleBiophysical journal2010
One-dimensional Brownian motion of charged nanoparticles along microtubules: a model system for weak binding interactions.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Space-Confined Hydrogel Particle-Based Biosensor for Early Warning of Aflatoxin B1 via Rapid Label-Free Fluorescence Detection of theAnalytical chemistry · 2025Article
- Amino acid transporters mediate autonomous delivery of nanoparticle vehicles into living plants.Nature communications · 2025Article
- Controlling the Quality of Nanodrugs According to Their New Property-Radiothermal Emission.Pharmaceutics · 2024Article
- pH-influenced self-assembled stealth nanoscaffolds encapsulating memantine for treatment of Alzheimer's disease.Journal of biosciences · 2023Article
- Tubulin tails and their modifications regulate protein diffusion on microtubules.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Multivalent electrostatic microtubule interactions of synthetic peptides are sufficient to mimic advanced MAP-like behavior.Molecular biology of the cell · 2019Article
- Application of spherical substrate to observe bacterial motility machineries by Quick-Freeze-Replica Electron Microscopy.Scientific reports · 2019Article
- Fluid heterogeneity detection based on the asymptotic distribution of the time-averaged mean squared displacement in single particle tracking experiments.Journal of physics. A, Mathematical and theoretical · 2018Article
- Assessing the Impact of Electrostatic Drag on Processive Molecular Motor Transport.Bulletin of mathematical biology · 2018Article
- Multiscale method for modeling binding phenomena involving large objects: application to kinesin motor domains motion along microtubules.Scientific reports · 2016Article
- A flipped ion pair at the dynein-microtubule interface is critical for dynein motility and ATPase activation.The Journal of cell biology · 2015Article
- Prime movers: the mechanochemistry of mitotic kinesins.Nature reviews. Molecular cell biology · 2014Review
- DNA condensation by partially acetylated poly(amido amine) dendrimers: effects of dendrimer charge density on complex formation.Molecules (Basel, Switzerland) · 2013Article
- Proteins searching for their target on DNA by one-dimensional diffusion: overcoming the "speed-stability" paradox.Journal of biological physics · 2013Article
- Paclitaxel-conjugated PAMAM dendrimers adversely affect microtubule structure through two independent modes of action.Biomacromolecules · 2013Article
- Tau protein diffuses along the microtubule lattice.The Journal of biological chemistry · 2012Article
- Electrostatically biased binding of kinesin to microtubules.PLoS biology · 2011Article
- Diffusion of myosin V on microtubules: a fine-tuned interaction for which E-hooks are dispensable.PloS one · 2011Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Various proteins are known to exhibit one-dimensional Brownian motion along charged rodlike polymers, such as microtubules (MTs), actin, and DNA. The electrostatic interaction between the proteins and the rodlike polymers appears to be crucial for one-dimensional Brownian motion, although the underlying mechanism has not been fully clarified. We examined the interactions of positively-charged nanoparticles composed of polyacrylamide gels with MTs. These hydrophilic nanoparticles bound to MTs and displayed one-dimensional Brownian motion in a charge-dependent manner, which indicates that nonspecific electrostatic interaction is sufficient for one-dimensional Brownian motion. The diffusion coefficient decreased exponentially with an increasing particle charge (with the exponent being 0.10 kBT per charge), whereas the duration of the interaction increased exponentially (exponent of 0.22 kBT per charge). These results can be explained semiquantitatively if one assumes that a particle repeats a cycle of binding to and movement along an MT until it finally dissociates from the MT. During the movement, a particle is still electrostatically constrained in the potential valley surrounding the MT. This entire process can be described by a three-state model analogous to the Michaelis-Menten scheme, in which the two parameters of the equilibrium constant between binding and movement, and the rate of dissociation from the MT, are derived as a function of the particle charge density. This study highlights the possibility that the weak binding interactions between proteins and rodlike polymers, e.g., MTs, are mediated by a similar, nonspecific charge-dependent mechanism.
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