ArticleBiophysical journal2010
Hydrophobic surfactant proteins induce a phosphatidylethanolamine to form cubic phases.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- The exosomal protein biomarkers auxiliary in diagnosis of interstitial lung disease.Respiratory research · 2025Article
- Effects of spontaneous curvature on interfacial adsorption and collapse of phospholipid monolayers.American journal of physiology. Lung cellular and molecular physiology · 2024Article
- The biophysical function of pulmonary surfactant.Biophysical journal · 2024Review
- Molecular Impact of Conventional and Electronic Cigarettes on Pulmonary Surfactant.International journal of molecular sciences · 2023Review
- The interaction of viral fusion peptides with lipid membranes.Biophysical journal · 2022Article
- Potential Therapeutic Applications of Pulmonary Surfactant Lipids in the Host Defence Against Respiratory Viral Infections.Frontiers in immunology · 2021Review
- Lipid-Protein and Protein-Protein Interactions in the Pulmonary Surfactant System and Their Role in Lung Homeostasis.International journal of molecular sciences · 2020Review
- The LLangmuir : the ACS journal of surfaces and colloids · 2018Article
- Divide & Conquer: Surfactant Protein SP-C and Cholesterol Modulate Phase Segregation in Lung Surfactant.Biophysical journal · 2017Article
- Pneumocytes Assemble Lung Surfactant as Highly Packed/Dehydrated States with Optimal Surface Activity.Biophysical journal · 2015Article
- Hydrophobic surfactant proteins strongly induce negative curvature.Biophysical journal · 2015Article
- Transient exposure of pulmonary surfactant to hyaluronan promotes structural and compositional transformations into a highly active state.The Journal of biological chemistry · 2013Article
- Structure-function correlations of pulmonary surfactant protein SP-B and the saposin-like family of proteins.European biophysics journal : EBJ · 2013Review
- An anionic phospholipid enables the hydrophobic surfactant proteins to alter spontaneous curvature.Biophysical journal · 2013Article
- Interaction of the C-terminal peptide of pulmonary surfactant protein B (SP-B) with a bicellar lipid mixture containing anionic lipid.PloS one · 2013Article
- Differential effects of the hydrophobic surfactant proteins on the formation of inverse bicontinuous cubic phases.Langmuir : the ACS journal of surfaces and colloids · 2012Article
- Lung surfactant protein A (SP-A) interactions with model lung surfactant lipids and an SP-B fragment.Biochemistry · 2011Article
- Lung surfactant protein SP-B promotes formation of bilayer reservoirs from monolayer and lipid transfer between the interface and subphase.Biophysical journal · 2011Article
- Direct simulation of protein-mediated vesicle fusion: lung surfactant protein B.Biophysical journal · 2010Article
- Lipid polymorphism induced by surfactant peptide SP-B(1-25).Biophysical journal · 2010Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The hydrophobic surfactant proteins SP-B and SP-C promote rapid adsorption of pulmonary surfactant to an air/water interface. Previous evidence suggests that they achieve this effect by facilitating the formation of a rate-limiting negatively curved stalk between the vesicular bilayer and the interface. To determine whether the proteins can alter the curvature of lipid leaflets, we used x-ray diffraction to investigate how the physiological mixture of these proteins affects structures formed by 1-palmitoyl-2-oleoyl phosphatidylethanolamine, which by itself undergoes the lamellar-to-inverse hexagonal phase transition at 71 degrees C. In amounts as low as 0.03% (w:w) and at temperatures as low as 57 degrees C, the proteins induce formation of bicontinuous inverse cubic phases. The proteins produce a dose-related shift of diffracted intensity to the cubic phases, with minimal evidence of other structures above 0.1% and 62 degrees C, but no change in the lattice-constants of the lamellar or cubic phases. The induction of the bicontinuous cubic phases, in which the individual lipid leaflets have the same saddle-shaped curvature as the hypothetical stalk-intermediate, supports the proposed model of how the surfactant proteins promote adsorption.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.