ArticleBiophysical journal2010
A biophysical model for integration of electrical, osmotic, and pH regulation in the human bronchial epithelium.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- A Mathematical Exploration of SDH-b Loss in Chromaffin Cells.Bulletin of mathematical biology · 2025Article
- Physiology and pathophysiology of human airway mucus.Physiological reviews · 2022Review
- KScientific reports · 2020Article
- A physiologically-motivated model of cystic fibrosis liquid and solute transport dynamics across primary human nasal epithelia.Journal of pharmacokinetics and pharmacodynamics · 2019Article
- Small molecule-facilitated anion transporters in cells for a novel therapeutic approach to cystic fibrosis.British journal of pharmacology · 2019Article
- An integrated mathematical epithelial cell model for airway surface liquid regulation by mechanical forces.Journal of theoretical biology · 2018Article
- A Mathematical Model Supports a Key Role for Ae4 (Slc4a9) in Salivary Gland Secretion.Bulletin of mathematical biology · 2018Article
- Mathematical model reveals role of nucleotide signaling in airway surface liquid homeostasis and its dysregulation in cystic fibrosis.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Article
- A spatial model of fluid recycling in the airways of the lung.Journal of theoretical biology · 2015Article
- Capturing intracellular pH dynamics by coupling its molecular mechanisms within a fully tractable mathematical model.PloS one · 2014Article
- Increased apical Na+ permeability in cystic fibrosis is supported by a quantitative model of epithelial ion transport.The Journal of physiology · 2013Article
- A mechanochemical model for auto-regulation of lung airway surface layer volume.Journal of theoretical biology · 2013Article
- Biophysical model of ion transport across human respiratory epithelia allows quantification of ion permeabilities.Biophysical journal · 2013Article
- Mathematical models of cystic fibrosis as a systemic disease.WIREs mechanisms of diseaseReview
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
A dynamical biophysical model for the functioning of an epithelium is presented. This model integrates the electrical and osmotic behaviors of the epithelium, taking into account intracellular conditions. The specific tissue modeled is the human bronchial epithelium, which is of particular interest, as it is the location of the most common lethal symptoms of cystic fibrosis. The model is implemented in a modular form to facilitate future application of the code to other epithelial tissue by inputting different transporters, channels, and geometric parameters. The model includes pH regulation as an integral component of overall regulation of epithelial function, through the interdependence of pH, bicarbonate concentration, and current. The procedures for specification, the validation of the model, and parametric studies are presented using available experimental data of cultured human bronchial epithelium. Parametric studies are performed to elucidate a), the contribution of basolateral chloride channels to the short-circuit current functional form, and b), the role that regulation of basolateral potassium conductance plays in epithelial function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.