ArticleBiophysical journal2010
Role of ATP-hydrolysis in the dynamics of a single actin filament.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Hydrolysis-dependent severing tunes internal monomeric heterogeneity to shape actin length distributions.bioRxiv : the preprint server for biology · 2025Article
- ATP levels influence cell movement during the mound phase in Dictyostelium discoideum as revealed by ATP visualization and simulation.FEBS open bio · 2022Article
- Spatiotemporal control of signal-driven enzymatic reaction in artificial cell-like polymersomes.Nature communications · 2022Article
- Effects of random hydrolysis on biofilament length distributions in a shared subunit pool.Biophysical journal · 2022Article
- Genome-wide CRISPR/Cas9 deletion screen defines mitochondrial gene essentiality and identifies routes for tumour cell viability in hypoxia.Communications biology · 2021Article
- Directional Migration of Breast Cancer Cells Hindered by Induced Electric Fields May Be Due to Accompanying Alteration of Metabolic Activity.Bioelectricity · 2021Article
- A stochastic model for dynamics of FtsZ filaments and the formation of Z -ring.The European physical journal. E, Soft matter · 2020Article
- Multiscale simulation of actin filaments and actin-associated proteins.Biophysical reviews · 2018Review
- Insights into the Cooperative Nature of ATP Hydrolysis in Actin Filaments.Biophysical journal · 2018Article
- Signatures of a macroscopic switching transition for a dynamic microtubule.Scientific reports · 2017Article
- Regulation of Microtubule Growth and Catastrophe: Unifying Theory and Experiment.Trends in cell biology · 2015Review
- Force-induced dynamical properties of multiple cytoskeletal filaments are distinct from that of single filaments.PloS one · 2014Article
- Microtubule dynamic instability: a new model with coupled GTP hydrolysis and multistep catastrophe.BioEssays : news and reviews in molecular, cellular and developmental biology · 2013Article
- Quantitative analysis of approaches to measure cooperative phosphate release in polymerized actin.Biophysical journal · 2012Article
- Random hydrolysis controls the dynamic instability of microtubules.Biophysical journal · 2012Article
- A theoretical analysis of filament length fluctuations in actin and other polymers.Journal of mathematical biology · 2011Article
- Microfluidics pushes forward microscopy analysis of actin dynamics.Bioarchitecture · 2011Article
- Individual actin filaments in a microfluidic flow reveal the mechanism of ATP hydrolysis and give insight into the properties of profilin.PLoS biology · 2011Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We study the stochastic dynamics of growth and shrinkage of single actin filaments taking into account insertion, removal, and ATP hydrolysis of subunits either according to the vectorial mechanism or to the random mechanism. In a previous work, we developed a model for a single actin or microtubule filament where hydrolysis occurred according to the vectorial mechanism: the filament could grow only from one end, and was in contact with a reservoir of monomers. Here we extend this approach in two ways--by including the dynamics of both ends and by comparing two possible mechanisms of ATP hydrolysis. Our emphasis is mainly on two possible limiting models for the mechanism of hydrolysis within a single filament, namely the vectorial or the random model. We propose a set of experiments to test the nature of the precise mechanism of hydrolysis within actin filaments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.