ArticleBiophysical journal2010
Form and function in cell motility: from fibroblasts to keratocytes.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 76 citations in OpenAlex.
- A low-cost electric micromanipulator and its application to single-cell electroporation.Biophysics and physicobiology · 2025Article
- Article
- Adhesion tunes speed and persistence by coordinating protrusions and extracellular matrix remodeling.Developmental cell · 2023Article
- Computational estimates of mechanical constraints on cell migration through the extracellular matrix.PLoS computational biology · 2020Article
- Multiscale modelling of motility wave propagation in cell migration.Scientific reports · 2020Article
- On the relation between filament density, force generation, and protrusion rate in mesenchymal cell motility.Molecular biology of the cell · 2018Article
- Computational modeling of single-cell mechanics and cytoskeletal mechanobiology.Wiley interdisciplinary reviews. Systems biology and medicine · 2018Review
- A free-boundary model of a motile cell explains turning behavior.PLoS computational biology · 2017Article
- Free boundary problem for cell protrusion formations: theoretical and numerical aspects.Journal of mathematical biology · 2017Article
- Crawling and turning in a minimal reaction-diffusion cell motility model: Coupling cell shape and biochemistry.Physical review. E · 2017Article
- Comparison of cell migration mechanical strategies in three-dimensional matrices: a computational study.Interface focus · 2016Article
- Effects of 3D geometries on cellular gradient sensing and polarization.Physical biology · 2016Article
- Computational analysis of amoeboid swimming at low Reynolds number.Journal of mathematical biology · 2016Article
- Actin-myosin spatial patterns from a simplified isotropic viscoelastic model.Biophysical journal · 2014Article
- A conservative algorithm for parabolic problems in domains with moving boundaries.Journal of computational physics · 2014Article
- A mathematical model of the coupled mechanisms of cell adhesion, contraction and spreading.Journal of mathematical biology · 2014Article
- Article
- Boyden chamber-based method for characterizing the distribution of adhesions and cytoskeletal structure in HT1080 fibrosarcoma cells.Cell adhesion & migration · 2014Article
- Periodic migration in a physical model of cells on micropatterns.Physical review letters · 2013Article
- Mathematical modeling of eukaryotic cell migration: insights beyond experiments.Annual review of cell and developmental biology · 2013Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
It is plain enough that a horse is made for running, but similar statements about motile cells are not so obvious. Here the basis for structure-function relations in cell motility is explored by application of a new computational technique that allows realistic three-dimensional simulations of cells migrating on flat substrata. With this approach, some cyber cells spontaneously display the classic irregular protrusion cycles and handmirror morphology of a crawling fibroblast, and others the steady gliding motility and crescent morphology of a fish keratocyte. The keratocyte motif is caused by optimal recycling of the cytoskeleton from the back to the front so that more of the periphery can be devoted to protrusion. These calculations are a step toward bridging the gap between the integrated mechanics and biophysics of whole cells and the microscopic molecular biology of cytoskeletal components.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.