ReviewImmunology2010
Immunological synapse: a multi-protein signalling cellular apparatus for controlling gene expression.
Review in Immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Necroptotic cell death and immunomodulator release induced by T-cell engaging anti-lymphoma therapies.Cell death & disease · 2026Article
- Single-chain variable fragment affinity tuning can optimize anti-AML CAR-NK cell functionality.Journal for immunotherapy of cancer · 2025Article
- Tumor Cell Communications as Promising Supramolecular Targets for Cancer Chemotherapy: A Possible Strategy.International journal of molecular sciences · 2024Review
- Coated recombinant target protein helps explore IL-1RAP CAR T-cell functionality in vitro.Immunologic research · 2023Article
- The transcription factor Mef2d regulates B:T synapse-dependent GC-TScience immunology · 2023Article
- Single-cell T cell receptor sequencing of paired human atherosclerotic plaques and blood reveals autoimmune-like features of expanded effector T cells.Nature cardiovascular research · 2023Article
- Review
- Maraviroc Is Associated with Latent HIV-1 Reactivation through NF-κB Activation in Resting CD4Journal of virology · 2018Article
- Mechanosensing in the immune response.Seminars in cell & developmental biology · 2017Review
- αII-spectrin in T cells is involved in the regulation of cell-cell contact leading to immunological synapse formation?PloS one · 2017Article
- Concerning immune synapses: a spatiotemporal timeline.F1000Research · 2016Review
- Review
- A novel T cell-based vaccine capable of stimulating long-term functional CTL memory against B16 melanoma via CD40L signaling.Cellular & molecular immunology · 2013Article
- "Cell biology meets physiology: functional organization of vertebrate plasma membranes"--the immunological synapse.Current topics in membranes · 2013Article
- Engineering T cell function using chimeric antigen receptors identified using a DNA library approach.PloS one · 2013Article
- HIV: cell binding and entry.Cold Spring Harbor perspectives in medicine · 2012Review
- Review
- Systems biology in immunology: a computational modeling perspective.Annual review of immunology · 2011Review
- Syntheses of fluorescent imidazoquinoline conjugates as probes of Toll-like receptor 7.Bioorganic & medicinal chemistry letters · 2010Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The interaction of T cells with antigen-presenting cells is the hallmark of adaptive immunity. In vitro studies have described the formation of an immunological synapse between these cells, and intra-vital imaging has described in great detail the dynamics of these interactions. The immunological synapse has become a paradigm to study signals exchanged between the two cells. A wealth of information has been amassed regarding the localization of signalling molecules, their kinetics and the transcription factors they activate. We continue to discover mechanisms that cause receptors and signalling molecules to compartmentalize in the cell; however, the emerging challenge lies in understanding how the immunological synapse contributes to differentiation. Here, we review some of the transcription factors activated downstream of T-cell receptor signalling and discuss mechanisms by which antigen dose and affinity may influence differentiation. Antigen affinity might change the kind of transcription factors that are activated whereas antigen dose is likely to influence the temporal dynamics of the transcription factors. The immunological synapse is therefore likely to influence differentiation by modulating the trafficking of transcription factors and by promoting asymmetric cell division, an emerging concept.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.