ArticleRespirology (Carlton, Vic.)2010
The Tennessee Children's Respiratory Initiative: Objectives, design and recruitment results of a prospective cohort study investigating infant viral respiratory illness and the development of asthma and allergic diseases.
Article in Respirology (Carlton, Vic.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 32 citations in OpenAlex.
- Interference Between Respiratory Syncytial Virus and Human Rhinovirus Infection in Infancy.The Journal of infectious diseases · 2017Trial
- Associations Between Prenatal Phthalate Exposure and Atopic Symptoms in Childhood: Effect Modification by Child Sex.Toxics · 2025Article
- Association of 17q12-q21 Asthma Risk Locus with Clinical Severity of Infant Respiratory Syncytial Virus Infection.Biomolecules · 2025Article
- The Design and Implementation of the ECOVIR Project: A Primary Health Care Surveillance System to Strengthen Co-Detection of Respiratory Viruses in Normandy.Methods and protocols · 2022Article
- [ECOVIR: Study of a primary care cohort in of patients with Acute Respiratory Infections in Normandy, an example of pluri-professional hospital-primary care coordination].Revue des maladies respiratoires · 2022Article
- A Respiratory Syncytial Virus Attachment Gene Variant Associated with More Severe Disease in Infants Decreases Fusion Protein Expression, Which May Facilitate Immune Evasion.Journal of virology · 2020Article
- Urine Levels of γ-Aminobutyric Acid Are Associated with the Severity of Respiratory Syncytial Virus Infection in Infancy.Annals of the American Thoracic Society · 2020Article
- Maternal Dietary Intake of Omega-3 Fatty Acids Correlates Positively with Regional Brain Volumes in 1-Month-Old Term Infants.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Viruses causing lower respiratory symptoms in young children: findings from the ORChID birth cohort.Thorax · 2018Observational
- A simple respiratory severity score that may be used in evaluation of acute respiratory infection.BMC research notes · 2016Article
- β2-Adrenergic receptor promoter haplotype influences the severity of acute viral respiratory tract infection during infancy: a prospective cohort study.BMC medical genetics · 2015Article
- Urine Club Cell 16-kDa Secretory Protein and Childhood Wheezing Illnesses After Lower Respiratory Tract Infections in Infancy.Pediatric allergy, immunology, and pulmonology · 2015Article
- Respiratory Severity Score Separates Upper Versus Lower Respiratory Tract Infections and Predicts Measures of Disease Severity.Pediatric allergy, immunology, and pulmonology · 2015Article
- Association between breast-feeding and severity of acute viral respiratory tract infection.The Pediatric infectious disease journal · 2014Article
- The Argentina Premature Asthma and Respiratory Team (APART): objectives, design, and recruitment results of a prospective cohort study of viruses and wheezing in very low birth weight infants.Advances in pediatric research · 2014Article
- Increased healthcare resource utilization for acute respiratory illness among Latino infants.The Journal of pediatrics · 2013Article
- Viral etiologies of infant bronchiolitis, croup and upper respiratory illness during 4 consecutive years.The Pediatric infectious disease journal · 2013Article
- Relationship of secondhand smoke and infant lower respiratory tract infection severity by familial atopy status.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2013Article
- Real-time reverse transcriptase PCR assay for improved detection of human metapneumovirus.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2012Article
- Influence of maternal asthma on the cause and severity of infant acute respiratory tract infections.The Journal of allergy and clinical immunology · 2012Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND AND
objectiveThe 'attack rate' of asthma following viral lower respiratory tract infections (LRTI) is about 3-4 fold higher than that of the general population; however, the majority of children who develop viral LRTI during infancy do not develop asthma, and asthma incidence has been observed to continuously decrease with age. Thus, we do not understand how viral LRTI either predispose or serve as a marker of children to develop asthma. The Tennessee Children's Respiratory Initiative has been established as a longitudinal prospective investigation of infants and their biological mothers. The primary goals are to investigate both the acute and the long-term health consequences of varying severity and aetiology of clinically significant viral respiratory tract infections on early childhood outcomes.
methodsOver four respiratory viral seasons, 2004–2008, term, predominantly non-low weight previously healthy infants and their biological mothers were enrolled during an infant's acute viral respiratory illness.Longitudinal follow up to age 6 years is ongoing [corrected].
resultsThis report describes the study objectives, design and recruitment results of the over 650 families enrolled in this longitudinal investigation. The Tennessee Children's Respiratory Initiative is additionally unique because it is designed in parallel with a large retrospective birth cohort of over 95,000 mother-infant dyads with similar objectives to investigate the role of respiratory viral infection severity and aetiology in the development of asthma.
conclusionsFuture reports from this cohort will help to clarify the complex relationship between infant respiratory viral infection severity, aetiology, atopic predisposition and the subsequent development of early childhood asthma and atopic diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.