Evidence map›Paper›PMID 20408844›Full record

ArticleBritish journal of haematology2010

Glutathione depletion enhances arsenic trioxide-induced apoptosis in lymphoma cells through mitochondrial-independent mechanisms.

Savita Bhalla, Leo I Gordon, Kevin David, Sheila Prachand, Amareshwar T K Singh, Shuo Yang, Jane N Winter, Dongsheng Guo, Thomas O'Halloran, Leonidas C Platanias and 1 more

Abstract readLetter
In one paragraph

Article in British journal of haematology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Article
  6. Effects of arsenic sulfide (AsBiomedical reports · 2013
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Savita Bhalla
Leo I Gordon
Kevin David
Sheila Prachand
Amareshwar T K Singh
Shuo Yang
Jane N Winter
Dongsheng Guo
Thomas O'Halloran
Leonidas C Platanias
Andrew M Evens

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniela E Matei · 1993 to 2026
$153.9M
Targeting Novel Protein Complexes for the Treatment of Acute Myeloid LeukemiaR01CA121192 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PLATANIAS, LEONIDAS C. · 2006 to 2023
$4.1M
Targeting the Mitochondria to Treat Lymphoma and MyelomaK23CA109613 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI EVENS, ANDREW M · 2005 to 2009
$657k
NCI NIH HHS K23 CA109613NCI NIH HHS K23 CA109613-A1NCI NIH HHS P30 CA060553NCI NIH HHS R01 CA121192NCI NIH HHS R01CA121192
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antineoplastic AgentsApoptosisArsenicalsArsenic TrioxideGlutathioneHumansLymphomaMitochondriaOxidesAntineoplastic AgentsArsenicalsArsenic TrioxideGlutathioneOxides

Identifiers

PMID20408844
PMCPMC2910124

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.