ArticleBiointerphases2008
Nanoparticle diffraction gratings for DNA detection on photopatterned glass substrates.
Article in Biointerphases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Rapid and PCR-free DNA Detection by Nanoaggregation-Enhanced Chemiluminescence.Scientific reports · 2017Article
- Silica nanowire arrays for diffraction-based bioaffinity sensing.Chemistry (Weinheim an der Bergstrasse, Germany) · 2014Article
- Nanostructured Substrates for Optical Sensing.The journal of physical chemistry letters · 2011Article
- Characterization and Application of Surface Plasmon-Enhanced Optical Diffraction from Electrodeposited Gold Nanowire Arrays.The journal of physical chemistry letters · 2011Article
- Ultrasensitive DNA microarray biosensing via in situ RNA transcription-based amplification and nanoparticle-enhanced SPR imaging.Journal of the American Chemical Society · 2011Article
- Fabricating nanoscale DNA patterns with gold nanowires.Analytical chemistry · 2010Article
- Fabrication of silica-coated gold nanorods functionalized with DNA for enhanced surface plasmon resonance imaging biosensing applications.Langmuir : the ACS journal of surfaces and colloids · 2009Article
- Characterization of electrodeposited gold and palladium nanowire gratings with optical diffraction measurements.Analytical chemistry · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
An ex situ nanoparticle DNA detection assay utilizing DNA-modified nanoparticles attached to DNA monolayer gratings on glass substrates is developed. The assay utilizes the simultaneous hybridization of a single stranded DNA (ssDNA) target molecule to both an amine-modified DNA oligonucleotide attached to an amine-reactive glass surface and a thiol-modified DNA oligonucleotide attached to a 13 nm gold nanoparticle. Surface plasmon resonance imaging measurements are used to characterize the two sequential hybridization adsorption processes employed in the assay, and fluorescence microscopy is used to characterize the formation of DNA monolayer gratings via the photopatterning of the amine-reactive glass slides. First order diffraction measurements utilizing incoherent collimated white light source and a 10 nm bandpass filter centered at 600 nm provided quantitative measurements of target ssDNA down to a concentration of 10 pM. Fourth order diffraction measurements employing a HeNe laser and avalanche photodiode were used to detect target ssDNA adsorption from 10 microl of a solution with a concentration as low as 10 fM, corresponding to 60,000 target DNA molecules. This simple yet sensitive grating-based nanoparticle DNA detection assay should be directly applicable for genetic screening, mRNA expression assays, and microRNA profiling.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.