Evidence map›Paper›PMID 20408564›Full record

ArticleChemical research in toxicology2010

Applying tobacco carcinogen and toxicant biomarkers in product regulation and cancer prevention.

Stephen S Hecht, Jian-Min Yuan, Dorothy Hatsukami

Registry-linked trialAbstract read
In one paragraph

Article in Chemical research in toxicology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01692353 (Evaluation of Cardiovascular Disease Biomarkers in Exclusive Smokers and Exclusive Moist Snuff Consumers), which is not on this map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01692353 completednot on this map

Evaluation of Cardiovascular Disease Biomarkers in Exclusive Smokers and Exclusive Moist Snuff Consumers

TypeobservationalSponsorR.J. Reynolds Tobacco CompanyRan2008 to 2009Enrolled168ConditionsCardiovascular Disease, Cigarette SmokingArmsSubject's usual brand (UB) tobacco product
3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 92 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Biomarkers of Tobacco Exposure Decrease After Smokers Switch to an E-Cigarette or Nicotine Gum.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019
    Trial
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Article
  9. Biomarkers of Exposure to Tobacco-Related Toxicants and Oxidative Stress Among Cancer Survivors.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Ethnic Differences of Urinary Cadmium in Cigarette Smokers from the Multiethnic Cohort Study.International journal of environmental research and public health · 2021
    Article
  14. Article
  15. Article
  16. Applying Tobacco, Environmental, and Dietary-Related Biomarkers to Understand Cancer Etiology and Evaluate Prevention Strategies.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020
    Article
  17. Review
  18. Review
  19. Article
  20. Biomarkers of Exposure among U.S. Adult Cigar Smokers: Population Assessment of Tobacco and Health (PATH) Study Wave 1 (2013-2014).Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Stephen S HechtMasonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA. hecht002@umn.edu
Jian-Min Yuan
Dorothy Hatsukami
University of Minnesota · US

Funding

TOBACCO REDUCTION STRATEGIES FOR PATIENTS WITH CARDIAC DISEASEP50DA013333 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI HATSUKAMI, DOROTHY K · 1999 to 2008
$16.8M
METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINESR01CA081301 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI STEPHEN S HECHT · 1999 to 2026
$7.1M
Metabolism of Carcinogenic Tobacco-Specific NitrosaminesR37CA081301 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI HECHT, STEPHEN S · 2004 to 2013
$5.5M
Benzo(a) pyrene Metabolism: Phenotyping and GenotypingR01CA092025 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI HECHT, STEPHEN S · 2001 to 2016
$5.0M
CARCINOGENIC CYCLIC NITROSAMINE DNA ADDUCTSR01CA085702 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI HECHT, STEPHEN S · 2000 to 2010
$3.3M
DNA Adducts of the Carcinogen AcetaldehydeR01ES011297 · NIEHS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI HECHT, STEPHEN S · 2002 to 2011
$3.1M
Biomarkers of NNK in prediction of lung cancer development in smokersR01CA129534 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YUAN, JIAN-MIN · 2009 to 2013
$2.8M
NCI NIH HHS CA-129534NCI NIH HHS CA-81301NCI NIH HHS CA-85702NCI NIH HHS CA-92025NCI NIH HHS N01-CP-64402NCI NIH HHS R01 CA081301NCI NIH HHS R01 CA085702NCI NIH HHS R01 CA092025NCI NIH HHS R01 CA129534NCI NIH HHS R37 CA081301NIDA NIH HHS DA-13333NIDA NIH HHS P50 DA013333NIEHS NIH HHS ES-11297NIEHS NIH HHS R01 ES011297
6 · The paper itself

Abstract

Tobacco carcinogen and toxicant biomarkers are metabolites or protein or DNA adducts of specific compounds in tobacco products. Highly reliable analytical methods, based mainly on mass spectrometry, have been developed and applied in large studies of many of these biomarkers. A panel of tobacco carcinogen and toxicant biomarkers is suggested here, and typical values for smokers and nonsmokers are summarized. This panel of biomarkers has potential applications in the new and challenging area of tobacco product regulation and in the development of rational approaches to cancer prevention by establishing carcinogen and toxicant uptake and excretion in people exposed to tobacco products.

Indexed as

Biomarkers, TumorCarcinogensHumansNeoplasmsSmokingTobacco ProductsBiomarkers, TumorCarcinogens

Identifiers

PMID20408564
PMCPMC2891118
OpenAlexW2056056592

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.