ArticleJournal of the American Chemical Society2010
Using isotopic tools to dissect and quantitate parallel metabolic pathways.
Article in Journal of the American Chemical Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- ACAD10 and ACAD11 allow entry of 4-hydroxy fatty acids into β-oxidation.Cellular and molecular life sciences : CMLS · 2024Article
- Synthesis of a novel isotopically labelled standard for quantification of γ-nonalactone in New Zealand Pinot noir via SIDA-SPE-GC-MS.Analytical and bioanalytical chemistry · 2023Article
- FluxFix: automatic isotopologue normalization for metabolic tracer analysis.BMC bioinformatics · 2016Article
- Cholesterol Analogs with Degradation-resistant Alkyl Side Chains Are Effective Mycobacterium tuberculosis Growth Inhibitors.The Journal of biological chemistry · 2016Article
- Catabolism of (2E)-4-hydroxy-2-nonenal via ω- and ω-1-oxidation stimulated by ketogenic diet.The Journal of biological chemistry · 2014Article
- Modular isotopomer synthesis of γ-hydroxybutyric acid for a quantitative analysis of metabolic fates.ACS chemical biology · 2014Article
- Glutathionylated 4-hydroxy-2-(E)-alkenal enantiomers in rat organs and their contributions toward the disposal of 4-hydroxy-2-(E)-nonenal in rat liver.Free radical biology & medicine · 2014Article
- Identification of a negative feedback loop in biological oxidant formation fegulated by 4-hydroxy-2-(E)-nonenal.Redox biology · 2014Article
- The EF loop in green proteorhodopsin affects conformation and photocycle dynamics.Biophysical journal · 2013Article
- 4-Hydroxy-2(E)-nonenal (HNE) catabolism and formation of HNE adducts are modulated by β oxidation of fatty acids in the isolated rat heart.Free radical biology & medicine · 2013Article
- Dietary regulation of catabolic disposal of 4-hydroxynonenal analogs in rat liver.Free radical biology & medicine · 2012Article
- Metabolomics, pathway regulation, and pathway discovery.The Journal of biological chemistry · 2011Review
- Isotopomer enrichment assay for very short chain fatty acids and its metabolic applications.Analytical biochemistry · 2011Article
- A mass spectrometric analysis of 4-hydroxy-2-(E)-nonenal modification of cytochrome c.Journal of mass spectrometry : JMS · 2011Article
- Metabolism of levulinate in perfused rat livers and live rats: conversion to the drug of abuse 4-hydroxypentanoate.The Journal of biological chemistry · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
4-Hydroxyacids are ubiquitous in human physiology. They are derived from the drugs of abuse gamma-hydroxybutyrate (GHB), gamma-hydroxypentanoate(GHP), in addition to the omnipresent lipid peroxidation product 4-hydroxy-2-(E)-nonenal (4-HNE). Previously we reported that 4-hydroxyacids are catabolized through two parallel pathways. In this report we detail two isotopic tools that have allowed the dissection of this catabolic process and illustrate how these tools can be used to quantify the relative flux down each pathway. We found that 4-hydroxynonanoate (4-hydroxyacid derived from 4-HNE) is primarly catabolized through a pathway that phosphorylates the C-4 hydroxyl and isomerizes it to a C-3 hydroxy compound, which is catabolized through beta-oxidation.
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