ArticleJournal of the Association for Research in Otolaryngology : JARO2010
K+ currents in isolated vestibular afferent calyx terminals.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Inhibition of Ionic Currents by Fluoxetine in Vestibular Calyces in Different Epithelial Loci.International journal of molecular sciences · 2024Article
- Expression of hyperpolarization-activated current (Journal of neurophysiology · 2023Article
- Dopaminergic Inhibition of NaFrontiers in neuroscience · 2021Article
- Persistent and resurgent NaJournal of neurophysiology · 2020Article
- KNeuroscience · 2020Article
- Regional and Developmental Differences in NaFrontiers in cellular neuroscience · 2018Article
- An allosteric gating model recapitulates the biophysical properties of IThe Journal of physiology · 2017Article
- AMPA receptor-mediated rapid EPSCs in vestibular calyx afferents.Journal of neurophysiology · 2017Article
- Accumulation of KThe Journal of physiology · 2017Article
- Kv1 channels and neural processing in vestibular calyx afferents.Frontiers in systems neuroscience · 2015Article
- Zonal variations in K+ currents in vestibular crista calyx terminals.Journal of neurophysiology · 2015Article
- Preliminary characterization of voltage-activated whole-cell currents in developing human vestibular hair cells and calyx afferent terminals.Journal of the Association for Research in Otolaryngology : JARO · 2014Article
- Mechanotransduction and hyperpolarization-activated currents contribute to spontaneous activity in mouse vestibular ganglion neurons.The Journal of general physiology · 2014Article
- Discharge regularity in the turtle posterior crista: comparisons between experiment and theory.Journal of neurophysiology · 2013Article
- Hyperpolarization-activated current (I(h)) in vestibular calyx terminals: characterization and role in shaping postsynaptic events.Journal of the Association for Research in Otolaryngology : JARO · 2012Article
- Modulation of neuronal sodium channels by the sea anemone peptide BDS-I.Journal of neurophysiology · 2012Article
- Postnatal expression of an apamin-sensitive k(ca) current in vestibular calyx terminals.The Journal of membrane biology · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Vestibular hair cells transduce mechanical displacements of their hair bundles into an electrical receptor potential which modulates transmitter release and subsequent action potential firing in afferent neurons. To probe ionic mechanisms underlying sensory coding in vestibular calyces, we used the whole-cell patch-clamp technique to record action potentials and K(+) currents from afferent calyx terminals isolated from the semicircular canals of Mongolian gerbils. Calyx terminals showed minimal current at the mean zero-current potential (-60 mV), but two types of outward K(+) currents were identified at potentials above -50 mV. The first current was a rapidly activating and inactivating K(+) current that was blocked by 4-aminopyridine (4-AP, 2.5 mM) and BDS-I (up to 250 nM). The time constant for activation of this current decreased with membrane depolarization to a minimum value of approximately 1 ms. The 4-AP-sensitive current showed steady-state inactivation with a half-inactivation of approximately -70 mV. A second, more slowly activating current (activation time constant was 8.5 +/- 0.7 ms at -8 mV) was sensitive to TEA (30 mM). The TEA-sensitive current also showed steady-state inactivation with a half-inactivation of -95.4 +/- 1.4 mV, following 500-ms duration conditioning pulses. A combination of 4-AP and TEA blocked approximately 90% of the total outward current. In current clamp, single Na(+)-dependent action potentials were evoked following hyperpolarization to potentials more negative than the resting potential. 4-AP application increased action potential width, whereas TEA both increased the width and greatly reduced repolarization of the action potential.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.