ArticleCellular and molecular neurobiology2010
Neurotrophin-4 (ntf4) mediates neurogenesis in mouse embryonic neural stem cells through the inhibition of the signal transducer and activator of transcription-3 (stat3) and the modulation of the activity of protein kinase B.
Article in Cellular and molecular neurobiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Transcriptomic insights into adenoid cystic carcinoma via RNA sequencing.Frontiers in genetics · 2023Article
- Bioengineered silkworm model for expressing human neurotrophin-4 with potential biomedical application.Frontiers in physiology · 2022Article
- The Pathogenesis and Therapeutic Approaches of Diabetic Neuropathy in the Retina.International journal of molecular sciences · 2021Review
- Exploration of the Immune-Related Signatures and Immune Infiltration Analysis in Melanoma.Analytical cellular pathology (Amsterdam) · 2021Article
- Upregulated NTF4 in colorectal cancer promotes tumor development via regulating autophagy.International journal of oncology · 2020Article
- Serum-mediated Activation of Bone Marrow-derived Mesenchymal Stem Cells in Ischemic Stroke Patients: A Novel Preconditioning Method.Cell transplantation · 2018Article
- Neurotrophin Signaling and Stem Cells-Implications for Neurodegenerative Diseases and Stem Cell Therapy.Molecular neurobiology · 2017Review
- Genome-wide patterns of copy number variation in the Chinese yak genome.BMC genomics · 2016Article
- Neurotrophic Factors and Their Potential Applications in Tissue Regeneration.Archivum immunologiae et therapiae experimentalis · 2016Review
- Article
- Genetics studies indicate that neural induction and early neuronal maturation are disturbed in autism.Frontiers in cellular neuroscience · 2014Article
- Interaction of Notch and gp130 signaling in the maintenance of neural stem and progenitor cells.Cellular and molecular neurobiology · 2014Review
- Brain site-specific proteome changes in aging-related dementia.Experimental & molecular medicine · 2013Article
- Gastrodia elata Blume (tianma) mobilizes neuro-protective capacities.International journal of biochemistry and molecular biology · 2012Article
- Tianma modulates blood vessel tonicity.The open biochemistry journal · 2012Article
- P60TRP interferes with the GPCR/secretase pathway to mediate neuronal survival and synaptogenesis.Journal of cellular and molecular medicine · 2011Article
- The novel protein MANI modulates neurogenesis and neurite-cone growth.Journal of cellular and molecular medicine · 2011Article
- miRNAs stem cell reprogramming for neuronal induction and differentiation.Molecular neurobiology · 2011Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of neurotrophin-4 (Ntf4) on mouse embryonic (day-14) neural stem cell (mE14-NSC) fate determination and the mechanisms involved were investigated. Using primary mE14-NSCs, immunocytochemistry and molecular-cell biological methods, such as Western-blotting, we characterized the effect of Ntf4 on mE14-NSC differentiation. Obtained in-vitro data revealed an interesting phenomenon of Ntf4 action resulting in enhanced mE14-NSC commitment to progenitor cells of the neuronal lineage. During this process, Ntf4 suppresses the interleukin 6 (Il6) family receptor and the Notch signalling pathways by modulating their specific receptor cleavages. The observed lineage commitment is controlled via an Ntf4-mediated modulation of protein kinase B (PKB/Akt) activity and characterized by a decreased Stat3 (signal transducer and activator of transcription-3) phosphorylation status. These findings suggest that the Ntf4-activated signalling cascade is responsible for initiating a concert among sheddases, kinases, and phosphatases to mediate neurogenesis.
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