ArticleJournal of Indian Society of Periodontology2009
Estimation of nitric oxide as an inflammatory marker in periodontitis.
Article in Journal of Indian Society of Periodontology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Indocyanine green-mediated antimicrobial photodynamic therapy as an adjunct to periodontal therapy: a systematic review and meta-analysis.Clinical oral investigations · 2021Pooled it
- Systemic oxidative stress biomarkers in chronic periodontitis: a meta-analysis.Disease markers · 2014Pooled it
- Efficacy of subantimicrobial-dose doxycycline against nitrosative stress in chronic periodontitis.Acta pharmacologica Sinica · 2013Trial
- In vivo and in vitro antidiabetic effects of phlorizin and its green-synthesized phlorizin-selenium nanoparticles in male rats: mechanistic involvements and nanoparticles characterization.Bioresources and bioprocessing · 2026Article
- Lumpy Skin Disease Virus (LSDV) recently emerged in Egypt: molecular detection, and assessment of the related hematobiochemical, and risk factors.BMC veterinary research · 2026Article
- Molecular Characterization, Oxidative Stress-Mediated Genotoxicity, and Hemato-Biochemical Changes in Domestic Water Buffaloes Naturally Infected withPathogens (Basel, Switzerland) · 2025Article
- Does a Single Episode of Pain from Impacted Third Molars Necessitate Their Removal?Journal of maxillofacial and oral surgery · 2024Article
- Modulation of the Nrf-2 and HO-1 signalling axis is associated with Betaine's abatement of fluoride-induced hepatorenal toxicities in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Anti-Inflammatory, Cytotoxic, and Genotoxic Effects of Soybean Oligopeptides Conjugated with Mannose.Foods (Basel, Switzerland) · 2024Article
- Salvimulticanol from3 Biotech · 2024Article
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- Unveiling Oxidative Stress-Induced Genotoxicity and Its Alleviation through Selenium and Vitamin E Therapy in Naturally Infected Cattle with Lumpy Skin Disease.Veterinary sciences · 2023Article
- Macrophages immunomodulation induced by Porphyromonas gingivalis and oral antimicrobial peptides.Odontology · 2023Review
- Zingerone-Induced Autophagy Suppresses IL-1β Production by Increasing the Intracellular Killing ofBiomedicines · 2023Article
- Renoprotection of Selected Antioxidant-Rich Foods (Water Spinach and Red Grape) and Probiotics in Gentamicin-Induced Nephrotoxicity and Oxidative Stress in Rats.Life (Basel, Switzerland) · 2022Article
- Short-term effect of ligature-induced periodontitis on cardiovascular variability and inflammatory response in spontaneously hypertensive rats.BMC oral health · 2021Article
- Article
- Monocyte Differentiation into Destructive Macrophages on In Vitro Administration of Gingival Crevicular Fluid from Periodontitis Patients.Journal of personalized medicine · 2021Article
- Localized probiotic-guided pocket recolonization in the treatment of chronic periodontitis: a randomized controlled clinical trial.Journal of periodontal & implant science · 2021Article
- Free amino acid composition of saliva in patients with healthy periodontium and periodontitis.Clinical oral investigations · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitric oxide (NO) is not only important in host defense and homeostasis but it is also regarded as harmful and has been implicated in the pathogenesis of a wide variety of inflammatory and autoimmune diseases. The presence of NO in periodontal disease may reflect the participation of an additional mediator of bone resorption responsible for disease progression. The aim of this study was to assess the level of NO in serum in chronic periodontitis, and correlate these levels with the severity of periodontal disease. Sixty subjects participated in the study and were divided into two groups. NO levels were assayed by measuring the accumulation of stable oxidative metabolite, nitrite with Griess reaction. Results showed subjects with periodontitis had significantly high nitrite in serum than healthy subjects. NO production is increased in periodontal disease, this will enable us to understand its role in disease progression and selective inhibition of NO may be of therapeutic utility in limiting the progression of periodontitis.
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Registered trials
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