ArticleEuropean journal of human genetics : EJHG2010
A genome-wide linkage scan reveals CD53 as an important regulator of innate TNF-alpha levels.
Article in European journal of human genetics : EJHG, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- The tetraspanin transmembrane protein CD53 mediates dyslipidemia and integrates inflammatory and metabolic signaling in hepatocytes.The Journal of biological chemistry · 2023Article
- Identification of key genes as predictive biomarkers for osteosarcoma metastasis using translational bioinformatics.Cancer cell international · 2021Article
- New immunological potential markers for triple negative breast cancer: IL18R1, CD53, TRIM, Jaw1, LTB, PTPRCAP.Discover oncology · 2021Article
- Bioinformatics analysis reveals novel hub gene pathways associated with IgA nephropathy.European journal of medical research · 2020Article
- Tetraspanin CD53 Promotes Lymphocyte Recirculation by Stabilizing L-Selectin Surface Expression.iScience · 2020Article
- Association between CD53 genetic polymorphisms and tuberculosis cases.Genes & genomics · 2019Article
- Antitumor Immunity Is Controlled by Tetraspanin Proteins.Frontiers in immunology · 2018Review
- Pathogen lineage-based genome-wide association study identified CD53 as susceptible locus in tuberculosis.Journal of human genetics · 2017Article
- The Mouse Papillomavirus Infection Model.Viruses · 2017Review
- Genetic association study of coronary collateral circulation in patients with coronary artery disease using 22 single nucleotide polymorphisms corresponding to 10 genes involved in postischemic neovascularization.BMC cardiovascular disorders · 2015Article
- Tetraspanins as therapeutic targets in hematological malignancy: a concise review.Frontiers in physiology · 2015Review
- Signatures of selection in sheep bred for resistance or susceptibility to gastrointestinal nematodes.BMC genomics · 2014Article
- Spontaneous mesotheliomas in F344/N rats are characterized by dysregulation of cellular growth and immune function pathways.Toxicologic pathology · 2014Article
- Article
- Identification of a major locus, TNF1, that controls BCG-triggered tumor necrosis factor production by leukocytes in an area hyperendemic for tuberculosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013Article
- Integrated cross-species transcriptional network analysis of metastatic susceptibility.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Article
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9 authors.
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Abstract
Cytokines are major immune system regulators. Previously, innate cytokine profiles determined by lipopolysaccharide stimulation were shown to be highly heritable. To identify regulating genes in innate immunity, we analyzed data from a genome-wide linkage scan using microsatellites in osteoarthritis (OA) patients (The GARP study) and their innate cytokine data on interleukin (IL)-1beta, IL-1Ra, IL-10 and tumor necrosis factor (TNF)alpha. A confirmation cohort consisted of the Leiden 85-Plus study. In this study, a linkage analysis was followed by manual selection of candidate genes in linkage regions showing LOD scores over 2.5. An single-nucleotide polymorphism (SNP) gene tagging method was applied to select SNPs on the basis of the highest level of gene tagging and possible functional effects. QTDT was used to identify the SNPs associated with innate cytokine production. Initial association signals were modeled by a linear mixed model. Through these analyses, we identified 10 putative genes involved in the regulation of TNFalpha. SNP rs6679497 in gene CD53 showed significant association with TNFalpha levels (P=0.001). No association of this SNP was observed with OA. A novel gene involved in the innate immune response of TNFalpha is identified. Genetic variation in this gene may have a role in diseases and disorders in which TNFalpha is closely involved.
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