ArticleBritish journal of cancer2010
Insulin-like growth factor-binding protein 7 alters the sensitivity to interferon-based anticancer therapy in hepatocellular carcinoma cells.
Article in British journal of cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 35 citations in OpenAlex.
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- Single-Cell RNA Sequencing Identifies Response of Renal Lymphatic Endothelial Cells to Acute Kidney Injury.Journal of the American Society of Nephrology : JASN · 2024Article
- A comprehensive prognostic and immune analysis of enhancer RNA identifies IGFBP7-AS1 as a novel prognostic biomarker in Uterine Corpus Endometrial Carcinoma.Biological procedures online · 2022Article
- Insulin Growth Factor Binding Protein 7 (IGFBP7)-Related Cancer and IGFBP3 and IGFBP7 Crosstalk.Frontiers in oncology · 2020Review
- Evaluation of the selenotranscriptome expression in two hepatocellular carcinoma cell lines.Analytical cellular pathology (Amsterdam) · 2015Article
- Generating new neurons to circumvent your fears: the role of IGF signaling.Cellular and molecular life sciences : CMLS · 2014Review
- Emerging role of insulin-like growth factor-binding protein 7 in hepatocellular carcinoma.Journal of hepatocellular carcinoma · 2014Review
- Combined IFN-α and 5-FU treatment as a postoperative adjuvant following surgery for hepatocellular carcinoma with portal venous tumor thrombus.Experimental and therapeutic medicine · 2013Article
- Downregulation of insulin-like growth factor-binding protein 7 in cisplatin-resistant non-small cell lung cancer.Cancer biology & therapy · 2012Article
- Insulin-like growth factor-binding protein-7 functions as a potential tumor suppressor in hepatocellular carcinoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2011Article
- A hippocampal insulin-growth factor 2 pathway regulates the extinction of fear memories.The EMBO journal · 2011Article
- A computational framework discovers new copy number variants with functional importance.PloS one · 2011Article
- Hepatocellular carcinoma, with portal thrombus after viral eradication, disappeared by 5-fluorouracil and interferon.World journal of hepatology · 2010Article
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13 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundA striking efficiency of interferon (IFN)-based anticancer therapy for advanced hepatocellular carcinoma (HCC) has been reported. Because its clinical efficiency greatly depends on each patient's local response, prediction of local response is crucial.
methodsContinuous exposure of IFN-alpha to parental PLC/PRF/5 cells (PLC-P) and a limiting dilution method resulted in the establishment of IFN-resistant cell clones (PLC-Rs). Microarray analyses of PLC-P and PLC-Rs identified insulin-like growth factor-binding protein 7 (IGFBP7) as one of the most significantly downregulated genes in PLC-Rs. Changes in anticancer effects of IFN-alpha were examined in HCC cells after genetic manipulation of IGFBP7 expression. The correlation between immunohistochemically determined IGFBP7 expression and the response to IFN-alpha/5-fluorouracil (5-FU) therapy was investigated in surgically resected HCC specimens.
resultsPLC-R cells showed a remarkable downregulation of IGFBP7 and resistance to IFN-alpha, compared with PLC-P. Parental PLC/PRF/5 cells transfected with short hairpin RNA against IGFBP7 showed a significant resistance to IFN-alpha relative to control cells (IC(50) fold increase=14.38 times). Insulin-like growth factor-binding protein 7 transfection into PLC-R restored sensitivity to IFN-alpha. In resected specimens, IGFBP7 expression significantly correlated with the response to IFN-alpha/5-FU therapy.
conclusionIGFBP7 could be a useful predictor of the response to IFN-based therapy in advanced HCC.
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