ArticleShock (Augusta, Ga.)2010
Relationship of basal heart rate variability to in vivo cytokine responses after endotoxin exposure.
Article in Shock (Augusta, Ga.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 62 citations in OpenAlex.
- Differential Patterns and Determinants of Cardiac Autonomic Nerve Dysfunction during Endotoxemia and Oral Fat Load in Humans.PloS one · 2015Trial
- Abnormal heart rate characteristics before clinical diagnosis of necrotizing enterocolitis.Journal of perinatology : official journal of the California Perinatal Association · 2013Trial
- Continuous enteral and parenteral feeding each reduces heart rate variability but differentially influences monocyte gene expression in humans.Shock (Augusta, Ga.) · 2012Trial
- The inciting factor for bradycardia in COVID-19 patients: a potential harm of steroid treatment.Journal of thoracic disease · 2024Article
- Autonomic dysfunction in COVID-19 patients receiving mechanical ventilation: A cross-sectional study.Sao Paulo medical journal = Revista paulista de medicina · 2023Article
- Heart rate variability and fatigue in MS: two parallel pathways representing disseminated inflammatory processes?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Review
- Transcutaneous Cervical Vagal Nerve Stimulation in Patients with Posttraumatic Stress Disorder (PTSD): A Pilot Study of Effects on PTSD Symptoms and Interleukin-6 Response to Stress.Journal of affective disorders reports · 2021Article
- Transcutaneous vagal nerve stimulation blocks stress-induced activation of Interleukin-6 and interferon-γ in posttraumatic stress disorder: A double-blind, randomized, sham-controlled trial.Brain, behavior, & immunity - health · 2020Article
- Heart rate variability: Measurement and emerging use in critical care medicine.Journal of the Intensive Care Society · 2020Review
- Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?Metabolic brain disease · 2019Review
- Esmolol indirectly stimulates vagal nerve activity in endotoxemic pigs.Intensive care medicine experimental · 2018Article
- A novel heart rate variability based risk prediction model for septic patients presenting to the emergency department.Medicine · 2018Observational
- Understanding Physiology in the Continuum: Integration of Information from Multiple -Frontiers in pharmacology · 2017Article
- Acute effect of zoledronic acid on the risk of cardiac dysrhythmias.Internal and emergency medicine · 2015Article
- Physiologic variability at the verge of systemic inflammation: multiscale entropy of heart rate variability is affected by very low doses of endotoxin.Shock (Augusta, Ga.) · 2015Article
- On heart rate variability and autonomic activity in homeostasis and in systemic inflammation.Mathematical biosciences · 2014Article
- Temporal metabolic profiling of plasma during endotoxemia in humans.Shock (Augusta, Ga.) · 2013Article
- Translational applications of evaluating physiologic variability in human endotoxemia.Journal of clinical monitoring and computing · 2013Review
- Heart rate and blood pressure variability in patients with myasthenia gravis.Annals of Indian Academy of Neurology · 2013Article
- Complexity science to conceptualize health and disease: is it relevant to clinical medicine?Mayo Clinic proceedings · 2012Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Autonomic inputs from the sympathetic and parasympathetic nervous systems, as measured by heart rate variability (HRV), have been reported to correlate to the severity injury and responses to infectious challenge among critically ill patients. In addition, parasympathetic/vagal activity has been shown experimentally to exert anti-inflammatory effects via attenuation of splanchnic tissue TNF-alpha production. We sought to define the influence of gender on HRV responses to in vivo endotoxin challenge in healthy humans and to determine if baseline HRV parameters correlated with endotoxin-mediated circulating cytokine responses. Young (<30 years of age), healthy subjects (n = 30) received endotoxin (2 ng/kg), and HRV and blood samples were obtained serially thereafter. Plasma cytokines were measured by enzyme-linked immunosorbent assay, and HRV parameters were determined by analysis of serial 5-min epochs of heart rate monitoring. In addition, calculation of multiscale entropy deriving from cardiac monitoring data was performed. The influence of factors such as gender, body mass index, and resting heart rate on HRV after endotoxin exposure was assessed. We found that gender, body mass index, or resting heart rate did not significantly alter the HRV response after endotoxin exposure. Using entropy analysis, we observed that females had significantly higher entropy values at 24 h after endotoxin exposure. Using a serially sampling protocol for cytokine determination, we found a significant correlation of several baseline HRV parameters (percentage of interval differences of successive interbeat intervals more than 50 ms, r = 0.42, P < 0.05; high-frequency variability, r = 0.4, P < 0.05; and low-frequency/high-frequency ratio, r = -0.43, P < 0.05) on TNF-alpha release after endotoxin exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.