ArticleThe Journal of clinical investigation2010
Mannose receptor interacts with Fc receptors and is critical for the development of crescentic glomerulonephritis in mice.
Article in The Journal of clinical investigation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 65 citations in OpenAlex.
- Alginate oligosaccharide prevents renal ischemia-reperfusion injury in rats via MRC1-mediated pathway.Acta pharmacologica Sinica · 2025Article
- NLRP3 inflammasome activity and pyroptosis are involved in CD206Acta biochimica et biophysica Sinica · 2025Article
- Sulfation at Glycopolymer Side Chains Switches Activity at the Macrophage Mannose Receptor (CD206) In Vitro and In Vivo.Journal of the American Chemical Society · 2022Article
- Gut dysbiosis is associated with acceleration of lupus nephritis.Scientific reports · 2022Article
- Carbohydrates from Pseudomonas aeruginosa biofilms interact with immune C-type lectins and interfere with their receptor function.NPJ biofilms and microbiomes · 2021Article
- A study of the possible role of Fab-glycosylated IgG in tumor immunity.Cancer immunology, immunotherapy : CII · 2021Article
- The Mannose Receptor: From Endocytic Receptor and Biomarker to Regulator of (Meta)Inflammation.Frontiers in immunology · 2021Review
- Pulmonary fate and consequences of transferrin-functionalized gold nanoparticles.Nanotheranostics · 2021Article
- Therapeutic Myeloperoxidase Inhibition Attenuates Neutrophil Activation, ANCA-Mediated Endothelial Damage, and Crescentic GN.Journal of the American Society of Nephrology : JASN · 2020Article
- Vangl2, a planar cell polarity molecule, is implicated in irreversible and reversible kidney glomerular injury.The Journal of pathology · 2018Article
- Mannose receptor modulates macrophage polarization and allergic inflammation through miR-511-3p.The Journal of allergy and clinical immunology · 2018Article
- Monocyte differentiation and macrophage priming are regulated differentially by pentraxins and their ligands.BMC immunology · 2017Article
- Autoantibody-induced internalization of CNS AQP4 water channel and EAAT2 glutamate transporter requires astrocytic Fc receptor.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Differences in the frequency of macrophage and T cell markers between focal and crescentic classes of anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis.Journal of nephropathology · 2017Article
- The function of cancer-shed gangliosides in macrophage phenotype: involvement with angiogenesis.Oncotarget · 2017Article
- miR-511-3p, embedded in the macrophage mannose receptor gene, contributes to intestinal inflammation.Mucosal immunology · 2016Article
- Macrophage heterogeneity in tissues: phenotypic diversity and functions.Immunological reviews · 2014Review
- Update on crescentic glomerulonephritis.Seminars in immunopathology · 2014Review
- Unique regulatory properties of mesangial cells are genetically determined in the rat.PloS one · 2014Article
- Molecular basis for downregulation of C5a-mediated inflammation by IgG1 immune complexes in allergy and asthma.Current allergy and asthma reports · 2013Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Crescentic glomerulonephritis (CGN), which frequently results in acute and chronic kidney disease, is characterized by and dependent on glomerular infiltration by macrophages. The mannose receptor (MR) is a pattern recognition receptor implicated in the uptake of endogenous and microbial ligands by macrophages, mesangial cells (MCs), and selected endothelial cells. It is upregulated on alternatively activated macrophages (i.e., macrophages associated with tissue repair and humoral immunity) and involved in antigen presentation to T cells. We used the mouse model of nephrotoxic nephritis to investigate the role of MR in CGN. Our results demonstrate what we believe to be a novel role for MR in the promotion of CGN that is independent of adaptive immune responses. MR-deficient (Mr-/-) mice were protected from CGN despite generating humoral and T cell responses similar to those of WT mice, but they demonstrated diminished macrophage and MC Fc receptor-mediated (FcR-mediated) functions, including phagocytosis and Fc-mediated oxygen burst activity. Mr-/- MCs demonstrated augmented apoptosis compared with WT cells, and this was associated with diminished Akt phosphorylation. Macrophage interaction with apoptotic MCs induced a noninflammatory phenotype that was more marked in Mr-/- macrophages than in WT macrophages. Our results demonstrate that MR augments Fc-mediated function and promotes MC survival. We suggest that targeting MR may provide an alternative therapeutic approach in CGN while minimizing the impact on adaptive immune responses, which are affected by conventional immunosuppressive approaches.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.