ReviewScience signaling2010
Competitive outgrowth of neural processes arising from long-distance cAMP signaling.
Review in Science signaling, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- TRPV2 interacts with actin and reorganizes submembranous actin cytoskeleton.Bioscience reports · 2020Article
- GEFs and Rac GTPases control directional specificity of neurite extension along the anterior-posterior axis.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Neuronal Cell Bodies Remotely Regulate Axonal Growth Response to Localized Netrin-1 Treatment via Second Messenger and DCC Dynamics.Frontiers in cellular neuroscience · 2016Article
- Activation of the cAMP Pathway Induces RACK1-Dependent Binding of β-Actin to BDNF Promoter.PloS one · 2016Article
- A-kinase anchoring proteins: cAMP compartmentalization in neurodegenerative and obstructive pulmonary diseases.British journal of pharmacology · 2014Review
- Calcium release-dependent actin flow in the leading process mediates axophilic migration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Novel GαS-protein signaling associated with membrane-tethered amyloid precursor protein intracellular domain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Type VI adenylyl cyclase regulates neurite extension by binding to Snapin and Snap25.Molecular and cellular biology · 2011Article
- Wnt/calcium signaling mediates axon growth and guidance in the developing corpus callosum.Developmental neurobiology · 2011Article
- Signaling mechanisms in cortical axon growth, guidance, and branching.Frontiers in neuroanatomy · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
During development, competition among undifferentiated neurites results in the growth of one neurite at the expense of the rest. This neurite becomes the axon. A similar competitive mechanism later governs the differential outgrowth of the axon and its branches. A long-range signal between different parts of the neuron is required to mediate this competition, but the nature of this signal was unknown. Recent work has shown that local cyclic adenosine monophosphate (cAMP) signaling promotes neurite growth but leads to decreased cAMP concentrations in distant neurites, thereby inhibiting their growth. The precise mechanism mediating long-distance cyclic nucleotide signaling is unclear but may involve localized calcium transients and autocrine signaling. Mutually inhibitory, competitive interactions during outgrowth of neural processes can emerge from these signaling events, both during axon specification and later during axon branching.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.