ArticleJournal of lipid research2010
Human luteinized granulosa cells secrete apoB100-containing lipoproteins.
Article in Journal of lipid research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 46 citations in OpenAlex.
- The role of metabolic reprogramming in oocyte development: research progress and prospects.Frontiers in reproductive health · 2026Review
- Implications of High-Density Cholesterol Metabolism for Oocyte Biology and Female Fertility.Frontiers in cell and developmental biology · 2022Review
- Lipid Metabolic Process Involved in Oocyte Maturation During Folliculogenesis.Frontiers in cell and developmental biology · 2022Review
- Role of Lipid Metabolism and Signaling in Mammalian Oocyte Maturation, Quality, and Acquisition of Competence.Frontiers in cell and developmental biology · 2021Review
- A Shift in Glycerolipid Metabolism Defines the Follicular Fluid of IVF Patients with Unexplained Infertility.Biomolecules · 2020Article
- The anti-inflammatory function of follicular fluid HDL and outcome of modified natural cycle in vitro fertilization†.Biology of reproduction · 2020Article
- Anti-oxidative function of follicular fluid HDL and outcomes of modified natural cycle-IVF.Scientific reports · 2019Article
- Lipid levels after childbirth and association with number of children: A population-based cohort study.PloS one · 2019Article
- Lipid Identification and Transcriptional Analysis of Controlling Enzymes in Bovine Ovarian Follicle.International journal of molecular sciences · 2018Article
- CoQ10 Supplementation in Patients Undergoing IVF-ET: The Relationship with Follicular Fluid Content and Oocyte Maturity.Antioxidants (Basel, Switzerland) · 2018Article
- Women's prepregnancy lipid levels and number of children: a Norwegian prospective population-based cohort study.BMJ open · 2018Article
- Developmental changes in polyunsaturated fetal plasma phospholipids and feto-maternal plasma phospholipid ratios and their association with bronchopulmonary dysplasia.European journal of nutrition · 2016Article
- Apolipoprotein B is regulated by gonadotropins and constitutes a predictive biomarker of IVF outcomes.Reproductive biology and endocrinology : RB&E · 2016Article
- Plasma phospholipids indicate impaired fatty acid homeostasis in preterm infants.European journal of nutrition · 2014Article
- Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease risk.Journal of lipid research · 2011Review
- Cumulus cells protect the oocyte against saturated free fatty acids.Animal reproductionArticle
- Androgen-Driven Dysregulation of Lipolysis in Cumulus Cells: Molecular Evidence and Metabolic Implications in Polycystic Ovary Syndrome.Reproductive medicine and biologyArticle
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thus far, liver, intestine, heart, and placenta have been shown to secrete apolipoprotein (apo)B-containing lipoproteins. In the present study, we first investigated lipoproteins in human follicular fluid (FF), surrounding developing oocytes within the ovary, as well as in corresponding plasma samples (n = 12). HDL cholesterol within FF correlated well with plasma HDL cholesterol (r = 0.80, P < 0.01), whereas VLDL cholesterol did not, indicating that VLDL in FF might originate directly from the granulosa cells producing FF. Primary human granulosa cells expressed apoB, microsomal triglyceride transfer protein, and apoE, but not the apoB-editing enzyme apobec-1. Using (3)H-leucine, we show that granulosa cells secrete apoB100-containing lipoproteins and that secretion can be stimulated by adding oleate to the medium (+83%). With electron microscopy, apoB-containing lipoproteins within the secretory pathway of human granulosa cells were directly visualized. Finally, we found a positive relationship between apoB levels in FF and improved fertility parameters in a population of 27 women undergoing in vitro fertilization. This study demonstrates that human granulosa cells assemble and secrete apoB100-containing lipoproteins, thereby identifying a novel cell type equipped with these properties. These results might have important implications for female infertility phenotypes as well as for the development of drugs targeting the VLDL production pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.