ArticleThe Journal of clinical investigation1991
Regulation of transforming growth factor expression in rat intestinal epithelial cell lines.
Article in The Journal of clinical investigation, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 107 citations in OpenAlex.
- Spirulina Crude Protein Promotes the Migration and Proliferation in IEC-6 Cells by Activating EGFR/MAPK Signaling Pathway.Marine drugs · 2019Article
- Toxicity of Pekinenin C from Euphorbia Pekinensis Radix on Rat Small Intestinal Crypt Epithelial Cell and Its Apoptotic Mechanism.International journal of molecular sciences · 2016Article
- Smad7 inhibits autocrine expression of TGF-β2 in intestinal epithelial cells in baboon necrotizing enterocolitis.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
- Antigen receptor V-segment usage in mucosal T cells.Immunology · 2008Article
- Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity.The Journal of clinical investigation · 2005Article
- Long term endocrine regulation of nucleoside transporters in rat intestinal epithelial cells.The Journal of general physiology · 2004Article
- The mechanisms of action of interleukin-1 on rabbit intestinal epithelial cells.Mediators of inflammation · 1999Article
- Cellular sources of transforming growth factor-beta isoforms in early and chronic radiation enteropathy.The American journal of pathology · 1998Article
- Regulation of mucosal immune responses: distinct antigens and antigen presenting cells.Journal of clinical immunology · 1997Review
- Human endometrial carcinoma cells release factors which inhibit the growth of normal epithelial cells in culture.Cell biology and toxicology · 1995Article
- NO chi generation by cultured small intestinal epithelial cells.Digestive diseases and sciences · 1995Article
- Synthesis and regulation of accessory/proinflammatory cytokines by intestinal epithelial cells.Clinical and experimental immunology · 1995Article
- Article
- Specific stimulation of basal lamina heparan sulfate proteoglycan in mouse uterine epithelium by Matrigel and by transforming growth factor-beta 1.In vitro cellular & developmental biology. Animal · 1994Article
- Functional interleukin-2 receptors on intestinal epithelial cells.The Journal of clinical investigation · 1993Article
- Identification and characterization of rat intestinal trefoil factor: tissue- and cell-specific member of the trefoil protein family.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Autocrine and paracrine modulation of transforming growth factor expression was assessed in rat intestinal epithelial cell lines designated IEC-6 and IEC-7. Addition of the transforming growth factor alpha (TGF alpha) homologue epidermal growth factor (EGF) to media of subconfluent IEC-6 cells led to autocrine stimulation of TGF alpha expression as well as increased expression of the transforming growth factor beta 1 (TGF beta 1). Increased expression of TGF alpha was maximal between 3 and 6 h after addition of EGF and subsequently declined coincident with increasing level of expression of TGF beta 1, which achieved maximal levels 6 h after addition of EGF and was sustained for more than 12 h. Addition of TGF beta 1 also led to autocrine induction of its own expression coincident with suppression of TGF alpha expression. Addition of TGF beta 1 was associated with increased expression of beta-actin when standardized to a constitutive transcript (GAPDH). Similar responses to addition of EGF and TGF beta 1, were observed in another intestinal epithelial cell line, designated IEC-17. Modulation of expression of TGFs was attenuated when cells were grown on the complex extracellular matrix produced by the Engelbreth-Holm-Swarm tumor (Matrigel), reflecting the baseline induction of TGF beta 1 expression when compared to IEC-6 and IEC-17 cells maintained on plastic. These observations suggest that expression of TGFs is controlled by autocrine mechanisms in intestinal epithelial cell lines and proliferation stimulated by TGF alpha may be initially self-reinforcing but ultimately downregulated by induction of TGF beta 1.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.