ArticleThe Journal of biological chemistry2010
Activation of polycystic kidney disease-2-like 1 (PKD2L1)-PKD1L3 complex by acid in mouse taste cells.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 53 citations in OpenAlex.
- Article
- Physiological functions and pharmacological targeting of transient receptor potential channels.Pharmacological reviews · 2025Review
- Primary cilia TRP channel regulates hippocampal excitability.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Polycystic kidney disease 2-like 1 channel contributes to the bitter aftertaste perception of quinine.Scientific reports · 2023Article
- Polycystin Channel Complexes.Annual review of physiology · 2023Review
- Structural basis for CaNature communications · 2021Article
- Adaptive selection drives TRPP3 loss-of-function in an Ethiopian population.Scientific reports · 2020Article
- Sensing Senses: Optical Biosensors to Study Gustation.Sensors (Basel, Switzerland) · 2020Review
- Cellular and Neural Responses to Sour Stimuli Require the Proton Channel Otop1.Current biology : CB · 2019Article
- Brain Imaging of Taste Perception in Obesity: a Review.Current nutrition reports · 2019Review
- Is there adaptation in the human genome for taste perception and phase I biotransformation?BMC evolutionary biology · 2019Article
- Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1.Nature communications · 2018Article
- Article
- Acid-induced off-response of PKD2L1 channel in Xenopus oocytes and its regulation by Ca(2.).Scientific reports · 2015Article
- PKD2L1/PKD1L3 channel complex with an alkali-activated mechanism and calcium-dependent inactivation.European biophysics journal : EBJ · 2015Article
- Permeation, regulation and control of expression of TRP channels by trace metal ions.Pflugers Archiv : European journal of physiology · 2015Review
- Polycystin-1 cleavage and the regulation of transcriptional pathways.Pediatric nephrology (Berlin, Germany) · 2014Review
- TRPs in taste and chemesthesis.Handbook of experimental pharmacology · 2014Review
- Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.Circulation. Cardiovascular genetics · 2013Article
- Putative interaction of brush cells with bicarbonate secreting cells in the proximal corpus mucosa.Frontiers in physiology · 2013Article
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Five basic tastes (bitter, sweet, umami, salty, and sour) are detected in the four taste areas where taste buds reside. Although molecular mechanisms for detecting bitter, sweet, and umami have been well clarified, those for sour and salty remain poorly understood. Several channels including acid-sensing ion channels have been proposed as candidate sour receptors, but they do not encompass all sour-sensing abilities in vivo. We recently reported a novel candidate for sour sensing, the polycystic kidney disease-2-like 1 (PKD2L1)-PKD1L3 channel complex. This channel is not a traditional ligand-gated channel and is gated open only after removal of an acid stimulus, called an off response. Here we show that off responses upon acid stimulus are clearly observed in native taste cells from circumvallate, but not fungiform papillae, of glutamate decarboxylase 67-green fluorescent protein (GAD67-GFP) knock-in mice, from which Type III taste cells can be visualized, using Ca(2+) imaging and patch clamp methods. Off responses were detected in most cells where PKD2L1 immunoreactivity was observed. Interestingly, the pH threshold for acid-evoked intracellular Ca(2+) increase was around 5.0, a value much higher than that observed in HEK293 cells expressing the PKD2L1-PKD1L3 complex. Thus, PKD2L1-PKD1L3-mediated acid-evoked off responses occurred both in HEK293 cells and in native taste cells, suggesting the involvement of the PKD2L1-PKD1L3 complex in acid sensing in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.