ArticleThe Journal of cell biology1991
Localization of dystrophin relative to acetylcholine receptor domains in electric tissue and adult and cultured skeletal muscle.
Article in The Journal of cell biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 145 citations in OpenAlex.
- Potential limitations of microdystrophin gene therapy for Duchenne muscular dystrophy.JCI insight · 2024Article
- NMJ-related diseases beyond the congenital myasthenic syndromes.Frontiers in cell and developmental biology · 2023Review
- SNTA1-deficient human cardiomyocytes demonstrate hypertrophic phenotype and calcium handling disorder.Stem cell research & therapy · 2022Article
- Microutrophin expression in dystrophic mice displays myofiber type differences in therapeutic effects.PLoS genetics · 2020Article
- Muscle-specific SIRT1 gain-of-function increases slow-twitch fibers and ameliorates pathophysiology in a mouse model of duchenne muscular dystrophy.PLoS genetics · 2014Article
- Becker muscular dystrophy-like myopathy regarded as so-called "fatty muscular dystrophy" in a pig: a case report and its diagnostic method.The Journal of veterinary medical science · 2014Article
- Syntrophin proteins as Santa Claus: role(s) in cell signal transduction.Cellular and molecular life sciences : CMLS · 2013Review
- Presynaptic calcium channels and α3-integrins are complexed with synaptic cleft laminins, cytoskeletal elements and active zone components.Journal of neurochemistry · 2010Article
- Truncated dystrophins can influence neuromuscular synapse structure.Molecular and cellular neurosciences · 2009Article
- The effects of glucocorticoid therapy on the inflammatory and dendritic cells in muscular dystrophies.International journal of experimental pathology · 2006Article
- C-terminal-truncated microdystrophin recruits dystrobrevin and syntrophin to the dystrophin-associated glycoprotein complex and reduces muscular dystrophy in symptomatic utrophin/dystrophin double-knockout mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2006Article
- Therapeutics for Duchenne muscular dystrophy: current approaches and future directions.Journal of molecular medicine (Berlin, Germany) · 2004Review
- Alpha1-syntrophin-deficient skeletal muscle exhibits hypertrophy and aberrant formation of neuromuscular junctions during regeneration.The Journal of cell biology · 2002Article
- Absence of alpha-syntrophin leads to structurally aberrant neuromuscular synapses deficient in utrophin.The Journal of cell biology · 2000Article
- A PDZ-containing scaffold related to the dystrophin complex at the basolateral membrane of epithelial cells.The Journal of cell biology · 1999Article
- Differential membrane localization and intermolecular associations of alpha-dystrobrevin isoforms in skeletal muscle.The Journal of cell biology · 1998Article
- Axon withdrawal during synapse elimination at the neuromuscular junction is accompanied by disassembly of the postsynaptic specialization and withdrawal of Schwann cell processes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- beta-Spectrin is colocalized with both voltage-gated sodium channels and ankyrinG at the adult rat neuromuscular junction.The Journal of cell biology · 1998Article
- Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteins.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Acetylcholine receptors in innervated muscles of dystrophic mdx mice degrade as after denervation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Two high-affinity mAbs were prepared against Torpedo dystrophin, an electric organ protein that is closely similar to human dystrophin, the gene product of the Duchenne muscular dystrophy locus. The antibodies were used to localize dystrophin relative to acetylcholine receptors (AChR) in electric organ and in skeletal muscle, and to show identity between Torpedo dystrophin and the previously described 270/300-kD Torpedo postsynaptic protein. Dystrophin was found in both AChR-rich and AChR-poor regions of the innervated face of the electroplaque. Immunogold experiments showed that AChR and dystrophin were closely intermingled in the AChR domains. In contrast, dystrophin appeared to be absent from many or all AChR-rich domains of the rat neuromuscular junction and of AChR clusters in cultured muscle (Xenopus laevis). It was present, however, in the immediately surrounding membrane (deep regions of the junctional folds, membrane domains interdigitating with and surrounding AChR domains within clusters). These results suggest that dystrophin may have a role in organization of AChR in electric tissue. Dystrophin is not, however, an obligatory component of AChR domains in muscle and, at the neuromuscular junction, its roles may be more related to organization of the junctional folds.
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Registered trials
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