ReviewJournal of cellular and molecular medicine2010
Moving towards in situ tracheal regeneration: the bionic tissue engineered transplantation approach.
Review in Journal of cellular and molecular medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Bio-Printed PCL Tracheal Graft in a Large Animal Model: Reproducible Short-Segment Regeneration and Preliminary Upgraded Long-Segment Reconstruction.Bioengineering (Basel, Switzerland) · 2026Article
- In situ vascularization and epithelialization of segmental bioengineered trachea based on marrow-derived stem/progenitor cells.Materials today. Bio · 2025Article
- Organic and Synthetic Substitutes in Tracheal Reconstruction: A Scoping Review (2015-2025).Bioengineering (Basel, Switzerland) · 2025Review
- A Contemporary Review of Trachea, Nose, and Ear Cartilage Bioengineering and Additive Manufacturing.Biomimetics (Basel, Switzerland) · 2024Review
- Synergistic Effects of SDS and HInternational journal of biomaterials · 2024Article
- Tracheal replacement with aortic grafts: Bench to clinical practice.Regenerative therapy · 2023Review
- Long-term longitudinal study on swine VML model.Biology direct · 2023Article
- Current Strategies for Tracheal Replacement: A Review.Life (Basel, Switzerland) · 2021Review
- Extracellular Matrix Scaffold Using Decellularized Cartilage for Hyaline Cartilage Regeneration.Advances in experimental medicine and biology · 2021Article
- Maneuvering the Migration and Differentiation of Stem Cells with Electrospun Nanofibers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Review
- Exploiting decellularized cochleae as scaffolds for inner ear tissue engineering.Stem cell research & therapy · 2017Article
- Mechanical Characterization and Constitutive Modeling of Human Trachea: Age and Gender Dependency.Materials (Basel, Switzerland) · 2016Article
- Effect of cell seeding on neotissue formation in a tissue engineered trachea.Journal of pediatric surgery · 2016Article
- In-vivo trachea regeneration: fabrication of a tissue-engineered trachea in nude mice using the body as a natural bioreactor.Surgery today · 2015Article
- In vivo generation of a mature and functional artificial skeletal muscle.EMBO molecular medicine · 2015Article
- Optimal amount of basic fibroblast growth factor in gelatin sponges incorporating β-tricalcium phosphate with chondrocytes.Tissue engineering. Part A · 2015Article
- Advances in tracheal reconstruction.Plastic and reconstructive surgery. Global open · 2014Review
- Future directions for the management of pain in osteoarthritis.International journal of clinical rheumatology · 2014Article
- Engineering functional epithelium for regenerative medicine and in vitro organ models: a review.Tissue engineering. Part B, Reviews · 2013Review
- Hydrogels preserve native phenotypes of valvular fibroblasts through an elasticity-regulated PI3K/AKT pathway.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In June 2008, the world's first whole tissue-engineered organ - the windpipe - was successfully transplanted into a 31-year-old lady, and about 18 months following surgery she is leading a near normal life without immunosuppression. This outcome has been achieved by employing three groundbreaking technologies of regenerative medicine: (i) a donor trachea first decellularized using a detergent (without denaturing the collagenous matrix), (ii) the two main autologous tracheal cells, namely mesenchymal stem cell derived cartilage-like cells and epithelial respiratory cells and (iii) a specifically designed bioreactor that reseed, before implantation, the in vitro pre-expanded and pre-differentiated autologous cells on the desired surfaces of the decellularized matrix. Given the long-term safety, efficacy and efforts using such a conventional approach and the potential advantages of regenerative implants to make them available for anyone, we have investigated a novel alternative concept how to fully avoid in vitro cell replication, expansion and differentiation, use the human native site as micro-niche, potentiate the human body's site-specific response by adding boosting, permissive and recruitment impulses in full respect of sociological and regulatory prerequisites. This tissue-engineered approach and ongoing research in airway transplantation is reviewed and presented here.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.