SynthesisBJOG : an international journal of obstetrics and gynaecology2010
What measured blood loss tells us about postpartum bleeding: a systematic review.
Synthesis in BJOG : an international journal of obstetrics and gynaecology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Mechanical and surgical interventions for treating primary postpartum haemorrhage.The Cochrane database of systematic reviews · 2020Pooled it
- Treatment for primary postpartum haemorrhage.The Cochrane database of systematic reviews · 2014Pooled it
- Calibrated delivery drape versus indirect gravimetric technique for the measurement of blood loss after delivery: a randomized trial.BMC pregnancy and childbirth · 2014Trial
- No reduction in instrumental vaginal births and no increased risk for adverse perineal outcome in nulliparous women giving birth on a birth seat: results of a Swedish randomized controlled trial.BMC pregnancy and childbirth · 2011Trial
- Article
- Ability of shock index and heart rate to predict the percentage of body blood volume lost after vaginal delivery as an indicator of severity: results from a prospective cohort study.Journal of global health · 2019Article
- Advancing Survival in Nigeria: A Pre-post Evaluation of an Integrated Maternal and Neonatal Health Program.Maternal and child health journal · 2018Article
- Efficacy of misoprostol for the treatment of postpartum hemorrhage: current knowledge and implications for health care planning.International journal of women's health · 2016Review
- Can inter-professional simulation training influence the frequency of blood transfusions after birth?Acta obstetricia et gynecologica Scandinavica · 2015Article
- Advancing maternal survival in the global context: are our strategies working?BMC public health · 2013Review
- Misoprostol for postpartum hemorrhage prevention at home birth: an integrative review of global implementation experience to date.BMC pregnancy and childbirth · 2013Review
- No excuse for ignoring methodologically sound studies.Journal of the Royal Society of Medicine · 2012Article
- Global maternal mortality rates.Reviews in obstetrics & gynecology · 2010Article
- Anesthesia technique and postpartum hemorrhage: a prospective cohort study.Brazilian journal of anesthesiology (Elsevier)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMeta-analyses of postpartum blood loss and the effect of uterotonics are biased by visually estimated blood loss.
objectivesTo conduct a systematic review of measured postpartum blood loss with and without prophylactic uterotonics for prevention of postpartum haemorrhage (PPH). SEARCH STRATEGY: We searched Medline and PubMed terms (labour stage, third) AND (ergonovine, ergonovine tartrate, methylergonovine, oxytocin, oxytocics or misoprostol) AND (postpartum haemorrhage or haemorrhage) and Cochrane reviews without any language restriction. SELECTION CRITERIA: Refereed publications in the period 1988-2007 reporting mean postpartum blood loss, PPH (> or =500 ml) or severe PPH (> or =1000 ml) following vaginal births. DATA COLLECTION AND ANALYSIS: Raw data were abstracted into Excel by one author and then reviewed by a co-author. Data were transferred to SPSS 17.0, and copied into RevMan 5.0 to perform random effects meta-analysis. MAIN
resultsThe distribution of average blood loss (29 studies) is similar with any prophylactic uterotonic, and is lower than without prophylaxis. Compared with no uterotonic, oxytocin and misoprostol have lower PPH (OR 0.43, 95% CI 0.23-0.81; OR 0.73, 95% CI 0.50-1.08, respectively) and severe PPH rates (OR 0.61, 95% CI 0.29-1.29; OR 0.74, 95% CI 0.52-1.04, respectively). Oxytocin has lower PPH (OR 0.65, 95% CI 0.60-0.70) and severe PPH (OR 0.71, 95% CI 0.56-0.91) rates than misoprostol, but not in developing countries.
conclusionOxytocin is superior to misoprostol in hospitals. Misoprostol substantially lowers PPH and severe PPH. A sound assessment of the relative merits of the two drugs is needed in rural areas of developing countries, where most PPH deaths occur.
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