ReviewEndocrine, metabolic & immune disorders drug targets2010
The genetics of obesity and the metabolic syndrome.
Review in Endocrine, metabolic & immune disorders drug targets, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 4 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Can biomarkers be used to improve diagnosis and prediction of metabolic syndrome in childhood cancer survivors? A systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021Pooled it
- Analysis of metabolic syndrome components in >15 000 african americans identifies pleiotropic variants: results from the population architecture using genomics and epidemiology study.Circulation. Cardiovascular genetics · 2014Pooled it
- Pleiotropic genes for metabolic syndrome and inflammation.Molecular genetics and metabolism · 2014Pooled it
- Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.Circulation. Cardiovascular genetics · 2012Pooled it
- Article
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- The Role of Adiponectin andGenes · 2025Review
- LGR4: A New Receptor Member in Endocrine and Metabolic Diseases.Endocrine reviews · 2023Review
- Mothers of small-bodied children and fathers of vigorous sons live longer.Frontiers in public health · 2023Article
- Precision medicine and metabolic syndrome.ARYA atherosclerosis · 2022Review
- Review
- "Big Data" Approaches for Prevention of the Metabolic Syndrome.Frontiers in genetics · 2022Review
- Study of DYRK1B gene expression and its association with metabolic syndrome in a small cohort of Egyptians.Molecular biology reports · 2021Article
- Genome-wide association analysis of metabolic syndrome quantitative traits in the GENNID multiethnic family study.Diabetology & metabolic syndrome · 2021Article
- E3 Ligase FBXW2 Is a New Therapeutic Target in Obesity and Atherosclerosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Race-specific alterations in DNA methylation among middle-aged African Americans and Whites with metabolic syndrome.Epigenetics · 2020Article
- Susceptibility loci for metabolic syndrome and metabolic components identified in Han Chinese: a multi-stage genome-wide association study.Journal of cellular and molecular medicine · 2017Article
- Metabolomic and Gene Expression Profiles Exhibit Modular Genetic and Dietary Structure Linking Metabolic Syndrome Phenotypes in Drosophila.G3 (Bethesda, Md.) · 2015Article
- Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
In this review, we discuss the genetic architecture of obesity and the metabolic syndrome, highlighting recent advances in identifying genetic variants and loci responsible for a portion of the variation in components of the metabolic syndrome, namely, adiposity traits, serum HDL and triglycerides, blood pressure, and glycemic traits. We focus particularly on recent progress from large-scale genome-wide association studies (GWAS), by detailing their successes and how lessons learned can pave the way for future discovery. Results from recent GWAS coalesce with earlier work suggesting numerous interconnections between obesity and the metabolic syndrome, developed through several potentially pleiotropic effects. We detail recent work by way of a case study on the cadherin 13 gene and its relation with adiponectin in the HyperGEN and the Framingham Heart Studies, and its association with obesity and the metabolic syndrome. We provide also a gene network analysis of recent variants related to obesity and metabolic syndrome discovered through genome-wide association studies, and 4 gene networks based on searching the NCBI database.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.