ReviewPathology oncology research : POR2011
The role of the bone marrow derived mesenchymal stem cells in colonic epithelial regeneration.
Review in Pathology oncology research : POR, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Role of mesenchymal stem cells in sepsis and their therapeutic potential in sepsis‑associated myopathy (Review).International journal of molecular medicine · 2024Review
- Colon Fibroblasts and Inflammation: Sparring Partners in Colorectal Cancer Initiation?Cancers · 2021Review
- Canine adipose tissue-derived mesenchymal stem cells pre-treated with TNF-alpha enhance immunomodulatory effects in inflammatory bowel disease in mice.Research in veterinary science · 2019Article
- Effect ofWorld journal of gastroenterology · 2017Article
- Regulation of S1P receptors and sphingosine kinases expression in acute pulmonary endothelial cell injury.PeerJ · 2016Article
- Association of hepatocyte-derived growth factor receptor/caudal type homeobox 2 co-expression with mucosal regeneration in active ulcerative colitis.World journal of gastroenterology · 2015Article
- Antiangiogenic Therapy Impedes Infiltration by CD4+ and CD8+ Cells Into an Early Colon Tumor.Journal of cancer prevention · 2015Article
- Longitudinal Tracing of Spontaneous Regression and Anti-angiogenic Response of Individual Microadenomas during Colon Tumorigenesis.Theranostics · 2015Article
- Over-expression of CXCR4 on mesenchymal stem cells protect against experimental colitis via immunomodulatory functions in impaired tissue.Journal of molecular histology · 2014Article
- Role of stromal-epithelial interaction in the formation and development of cancer cells.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2013Article
- The possible role of mesenchymal stem cells therapy in the repair of experimentally induced colitis in male albino rats.International journal of stem cells · 2013Article
- Polarized neural stem cells derived from adult bone marrow stromal cells develop a rosette-like structure.In vitro cellular & developmental biology. Animal · 2013Article
- Bone-marrow mesenchymal stem cells reduce rat intestinal ischemia-reperfusion injury, ZO-1 downregulation and tight junction disruption via a TNF-α-regulated mechanism.World journal of gastroenterology · 2013Article
- Adipose-derived mesenchymal cells for bone regereneration: state of the art.BioMed research international · 2013Review
- Heparin-binding epidermal growth factor-like growth factor protects mesenchymal stem cells.The Journal of surgical research · 2012Article
- Physiological and pathological role of local and immigrating colonic stem cells.World journal of gastroenterology · 2012Review
- Mesenchymal stem cells and acute lung injury.Critical care clinics · 2011Review
- Isolated lymphoid follicles in colon: switch points between inflammation and colorectal cancer?World journal of gastroenterology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone marrow derived mesenchymal stem cells (BM-MSCs) take part in the colonic mucosal regeneration. They are multipotent cells, which can be identified with both negative (i.e. CD13, CD 14, CD45, c-Kit, major histocompatibility complex /MHC class I and II) and positive (i.e. CD54 (ICAM1), CD133, CD146 (MCAM), CD166, Flk-1, Sca-1, Thy-1, stage-specific antigen I /SSEA-I and Musashi-1, HLA class I) markers. These cells can repopulate the gastrointestinal mucosa as they may differentiate into stromal- (i.e. myofi-broblast) or epithelial-like (Paneth-, epithel-, goblet or enteroendocrin) cells without proliferation. During the mesenchymal to epithelial transition (MET) stem cells enter the epithelial layer and take up epithelial cell-like properties. Rarely BM-MSCs may retain their stem cell characteristics and are capable of producing progeny. The isolated lymphoid aggregates may serve as a platform from where BM-MSCs migrate to the nearby crypts as mediated by several chemoattractant proteins, which are expressed in injured tissue. The number of BM-MSCs is influenced by the degree of inflammation. In this review we summarize the current information about the role of BM-MSCs in the repair progress of injured colonic epithelium and their potential clinical applications.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.