ReviewDigestive diseases and sciences2010
The case for endoscopic treatment of non-dysplastic and low-grade dysplastic Barrett's esophagus.
Review in Digestive diseases and sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02793479 (National Registry for Radiofrequency Ablation in Patients With Barrett's Esophagus), which is not on this map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
National Registry for Radiofrequency Ablation in Patients With Barrett's Esophagus
Who cites it
21 citing papers in PubMed, 63 citations in OpenAlex.
- A microRNA Signature Identifies Patients at Risk of Barrett Esophagus Progression to Dysplasia and Cancer.Digestive diseases and sciences · 2022Article
- Management of nondysplastic Barrett's esophagus: When to survey? When to ablate?Therapeutic advances in chronic disease · 2022Review
- Antireflux Surgery and Barrett's Esophagus: Myth or Reality?World journal of surgery · 2018Article
- The Durability of Endoscopic Therapy for Treatment of Barrett's Metaplasia, Dysplasia, and Mucosal Cancer After Nissen Fundoplication.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2015Article
- Endoscopic treatments for dysplastic Barrett's esophagus: resection, ablation, what else?World journal of surgery · 2015Review
- Evidence-based endoscopic management of Barrett's esophagus.Gastroenterology report · 2015Review
- Preference of endoscopic ablation over medical prevention of esophageal adenocarcinoma by patients with Barrett's esophagus.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2015Article
- Review on novel concepts of columnar lined esophagus.Wiener klinische Wochenschrift · 2013Review
- Managing Barrett's esophagus with radiofrequency ablation.Gastroenterology report · 2013Article
- Diagnosis and management of Barrett's metaplasia: What's new.World journal of gastrointestinal endoscopy · 2012Article
- Management of Barrett's oesophagus and intramucosal oesophageal cancer: a review of recent development.Therapeutic advances in gastroenterology · 2012Article
- Buried (but not dead) Barrett's metaplasia: tales from the crypts.Gastrointestinal endoscopy · 2012Article
- Management of nondysplastic barrett esophagus with ablation therapy.Gastroenterology & hepatology · 2011Article
- Barrett's Esophagus without dysplasia: wait or ablate?Digestive diseases and sciences · 2011Article
- Ablative therapies for Barrett's esophagus.Current gastroenterology reports · 2011Review
- Barrett's esophagus: a review of the literature.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2011Review
- "War and Peace" with Barrett's esophagus.Digestive diseases and sciences · 2011Article
- Barrett's esophagus: Clinical issues.Gastrointestinal endoscopy clinics of North America · 2011Review
- Treatment of GERD complications (Barrett's, peptic stricture) and extra-oesophageal syndromes.Best practice & research. Clinical gastroenterology · 2010Review
- Radiofrequency ablation of Barrett's esophagus: let's not get ahead of ourselves.Digestive diseases and sciences · 2010Article
Corrections and comments
- Commented on by
Authors and funding
16 authors at 15 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-dysplastic mucosa (ND-) in Barrett's esophagus (BE) shows clonal molecular aberrations, loss of cell cycle control, and other features of "neoplasia." These changes occur prior to morphologic expression of neoplasia (dysplasia). Morphologic evaluation of dysplasia is fraught with error, and, as a result, often leads to false-negative and false-positive diagnoses. Early "crypt dysplasia" is difficult to detect, and is often missed in routine biopsy specimens. Some studies show substantial progression rates of low-grade dysplasia (LGD), and crypt dysplasia, to esophageal adenocarcinoma (EAC). Dysplasia, even when fully developed, may, in certain circumstances, be difficult to differentiate from non-dysplastic (regenerating) BE. Radiofrequency ablation (RFA) is a safe and effective method for removing mucosa at risk of cancer. Given the difficulties of dysplasia assessment in mucosal biopsies, and the molecular characteristics of ND-BE, this technique should be considered for treatment of all BE patients, including those with ND or LGD. Post-ablation neo-squamous epithelium reveals no molecular abnormalities, and is biologically stable. Given that prospective randomized controlled trials of ablative therapy for ND-BE aiming at reducing EAC incidence and mortality are unlikely to be completed in the near future, endoscopic ablation is a valid management option. The success of RFA in achieving safe, uniform, reliable, and predictable elimination of BE allows surgeons to combine fundoplication with RFA. Currently, there is no type of treatment for dysplastic or non-dysplastic BE that achieves a complete response in 100% of patients, eliminates all risk of developing cancer, results in zero adverse events, is less expensive in terms of absolute costs than surveillance, is durable for 20+ years, or eliminates the need for surveillance. Regardless, RFA shows established safety, efficacy, durability, and cost-effective profiles that should be considered in the management of patients with non-dysplastic or low-grade dysplastic BE.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.