ArticleThe European physical journal. E, Soft matter2010
Influence of cholesterol on the collective dynamics of the phospholipid acyl chains in model membranes.
Article in The European physical journal. E, Soft matter, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Aspirin locally disrupts the liquid-ordered phase.Royal Society open science · 2018Article
- The Effects of the Structure and Composition of the Hydrophobic Parts of Phosphatidylcholine-Containing Systems on Phosphatidylcholine Oxidation by Ozone.The Journal of membrane biology · 2017Article
- On scattered waves and lipid domains: detecting membrane rafts with X-rays and neutrons.Soft matter · 2015Article
- Correlation between supercoiling and conformational motions of the bacterial flagellar filament.Biophysical journal · 2013Article
- Article
- Effect of cholesterol on the lateral nanoscale dynamics of fluid membranes.European biophysics journal : EBJ · 2012Article
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Authors and funding
7 authors.
Funding
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Abstract
We have studied the packing and collective dynamics of the phospholipid acyl chains in a model membrane composed of 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine (DMPC) and cholesterol in varied phase state. After a structural characterization of this two-component model bilayer using X-ray reflectivity, we have carried out coherent inelastic neutron scattering to investigate the chain dynamics. Both DMPC/cholesterol membranes exhibited much sharper and more pronounced low-energy inelastic excitations than a pure DMPC membrane. In the high-energy regime above 10 meV, the insertion of cholesterol into the membrane was found to shift the position of the inelastic excitation towards values otherwise found in the pure lipids gel phase. Thus, the dissipative collective short-range dynamics of the acyl chains is strongly influenced by the presence of cholesterol.
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Registered trials
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