ArticleEuropean journal of clinical pharmacology2010
Non-steroidal anti-inflammatory drugs: use and co-treatment with potentially interacting medications in the elderly.
Article in European journal of clinical pharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 51 citations in OpenAlex.
- Norfloxacin-NSAID Pharmaceutical Salts: Structure-Property Relationships for Enhanced Solubility and Stability.Crystal growth & design · 2026Article
- Study of Behaviors Related to Over-the-Counter Medications, in Particular Nonsteroidal Anti-Inflammatory Drugs, in the General Polish Population.Healthcare (Basel, Switzerland) · 2026Article
- Multimorbidity quantification from the perspective of precision management: challenges and strategies.Annals of medicine · 2025Review
- Clinical Pharmaceutical Care in Nursing Home Residents as a Cornerstone for Drug-Related Problems Identification.Clinical and translational science · 2025Observational
- Nonvitamin K Anticoagulants: Risk of Bleeding When Interacting With Other Medications: A Cohort Study From Medicare.Clinical cardiology · 2024Observational
- Review
- Over the Counter Pain Medications Used by Adults: A Need for Pharmacist Intervention.International journal of environmental research and public health · 2023Article
- Article
- Safety of Non-Steroidal Anti-Inflammatory Drugs in the Elderly: An Analysis of Published Literature and Reports Sent to the Portuguese Pharmacovigilance System.International journal of environmental research and public health · 2022Review
- Prevalence of non-steroidal anti-inflammatory drugs (NSAIDs) use in patients with hypertensive crisis.Health science reports · 2022Article
- The global, regional and national burden of peptic ulcer disease from 1990 to 2019: a population-based study.BMC gastroenterology · 2022Article
- Safety risk associated with use of nonsteroidal anti-inflammatory drugs in Japanese elderly compared with younger patients with osteoarthritis and/or chronic low back pain: A retrospective database study.Pain practice : the official journal of World Institute of Pain · 2022Article
- The Potential Role of Fish-Derived Protein Hydrolysates on Metabolic Health, Skeletal Muscle Mass and Function in Ageing.Nutrients · 2020Review
- Article
- A Comprehensive Review of Non-Steroidal Anti-Inflammatory Drug Use in The Elderly.Aging and disease · 2018Review
- Chronic Pain: How Challenging Are DDIs in the Analgesic Treatment of Inpatients with Multiple Chronic Conditions?PloS one · 2017Article
- [DGRh recommendations for the implementation of current security aspects in the NSAID treatment of musculoskeletal pain].Zeitschrift fur Rheumatologie · 2016Review
- Drug interactions in dying patients: a retrospective analysis of hospice inpatients in Germany.Drug safety · 2012Article
- Inappropriate prescribing for older people admitted to an intermediate-care nursing home unit and hospital wards.Scandinavian journal of primary health care · 2012Article
- [Potential interactions of rheumatologic medications in the elderly].Der Orthopade · 2012Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNon-steroidal anti-inflammatory drugs (NSAIDs) are widely used in the elderly. NSAIDs may cause a series of adverse drug reactions, of which gastrointestinal, renovascular/cardiovascular and bleeding complications are of particular concern. Concomitant use of several other drugs may further increase the risk of these adverse effects.
objectiveTo examine the extent of chronic use of NSAIDs and co-prescription of drugs which may seriously interact with NSAIDs in elderly subjects, by using data from the Norwegian Prescription Database.
resultsA total of 7.3% of all individuals (71,681/984,457) over 60 years of age filled at least one prescription for reimbursed NSAIDs during the 1-year study period (2006). Co-prescription of medications which may interact with NSAIDs was prevalent for drugs used for hypertension and/or heart failure (59.5%), antithrombotic drugs (35.1%), systemic glucocorticoids (12.9%) and SSRI antidepressants (8.3%). As many as 4.8 and 3.8% of NSAID users were co-prescribed warfarin or oral methotrexate respectively.
conclusionThe frequent co-prescription of medications which may cause detrimental interactions in elderly chronic NSAID users adds to safety concerns regarding this widely prescribed class of drugs.
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