ArticlePloS one2010
Cell-extrinsic defective lymphocyte development in Lmna(-/-) mice.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Nuclear mechanobiology rules immune cells' functions: from differentiation to cell trafficking and pathogen killing.Nucleus (Austin, Tex.) · 2026Review
- Thymulin restrains age-associated myeloid inflammation and enhances cancer immunotherapy.Nature communications · 2026Article
- B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses.FEBS letters · 2025Review
- Lamin A/C and the Immune System: One Intermediate Filament, Many Faces.International journal of molecular sciences · 2020Review
- Epigenomic drivers of immune dysfunction in aging.Aging cell · 2019Review
- Lamin A/C augments Th1 differentiation and response against vaccinia virus and Leishmania major.Cell death & disease · 2018Article
- Article
- [Myeloid and erythroid hematopoietic transcription factor expression decline after knockdown ofZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2016Article
- Infection susceptibility and immune senescence with advancing age replicated in accelerated aging Lmna(Dhe) mice.Aging cell · 2015Article
- Nuclear envelope lamin-A couples actin dynamics with immunological synapse architecture and T cell activation.Science signaling · 2014Article
- Lamins regulate cell trafficking and lineage maturation of adult human hematopoietic cells.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Accumulation of prelamin A compromises NF-κB-regulated B-lymphopoiesis in a progeria mouse model.Longevity & healthspan · 2013Article
- Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response.Genes & development · 2012Article
- Laminopathies: the molecular background of the disease and the prospects for its treatment.Cellular & molecular biology letters · 2011Review
- Nuclear mechanics during cell migration.Current opinion in cell biology · 2011Article
- Nuclear envelope lamin-A as a coordinator of T cell activation.Nucleus (Austin, Tex.)Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMutations in the LMNA gene, which encodes all A-type lamins, result in a variety of human diseases termed laminopathies. Lmna(-/-) mice appear normal at birth but become runted as early as 2 weeks of age and develop multiple tissue defects that mimic some aspects of human laminopathies. Lmna(-/-) mice also display smaller spleens and thymuses. In this study, we investigated whether altered lymphoid organ sizes are correlated with specific defects in lymphocyte development. PRINCIPAL
findingsLmna(-/-) mice displayed severe age-dependent defects in T and B cell development which coincided with runting. Lmna(-/-) bone marrow reconstituted normal T and B cell development in irradiated wild-type recipients, driving generation of functional and self-MHC restricted CD4(+) and CD8(+) T cells. Transplantation of Lmna(-/-) neonatal thymus lobes into syngeneic wild-type recipients resulted in good engraftment of thymic tissue and normal thymocyte development.
conclusionsCollectively, these data demonstrate that the severe defects in lymphocyte development that characterize Lmna(-/-) mice do not result directly from the loss of A-type lamin function in lymphocytes or thymic stroma. Instead, the immune defects in Lmna(-/-) mice likely reflect indirect damage, perhaps resulting from prolonged stress due to the striated muscle dystrophies that occur in these mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.