ArticlePloS one2010
Groucho-mediated repression may result from a histone deacetylase-dependent increase in nucleosome density.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- The homeobox transcription factor MNX1 regulates the expression of many non-MN-specific neuronal genes in motor neurons.Nucleic acids research · 2025Article
- Mechanisms of Groucho-mediated repression revealed by genome-wide analysis of Groucho binding and activity.BMC genomics · 2017Article
- Drosophila poised enhancers are generated during tissue patterning with the help of repression.Genome research · 2017Article
- Selection of cell fate in the organ of Corti involves the integration of Hes/Hey signaling at the Atoh1 promoter.Development (Cambridge, England) · 2016Article
- The Central Region of the Drosophila Co-repressor Groucho as a Regulatory Hub.The Journal of biological chemistry · 2015Article
- A Repressor Protein Complex Regulates Leaf Growth in Arabidopsis.The Plant cell · 2015Article
- p15RS/RPRD1A (p15INK4b-related sequence/regulation of nuclear pre-mRNA domain-containing protein 1A) interacts with HDAC2 in inhibition of the Wnt/β-catenin signaling pathway.The Journal of biological chemistry · 2015Article
- Recent insights into Groucho co-repressor recruitment and function.Transcription · 2015Article
- The Groucho co-repressor is primarily recruited to local target sites in active chromatin to attenuate transcription.PLoS genetics · 2014Article
- Brinker possesses multiple mechanisms for repression because its primary co-repressor, Groucho, may be unavailable in some cell types.Development (Cambridge, England) · 2013Article
- Multi-study integration of brain cancer transcriptomes reveals organ-level molecular signatures.PLoS computational biology · 2013Article
- The unconserved groucho central region is essential for viability and modulates target gene specificity.PloS one · 2012Article
- Transcript levels of ten caste-related genes in adult diploid males of Melipona quadrifasciata (Hymenoptera, Apidae) - A comparison with haploid males, queens and workers.Genetics and molecular biology · 2011Article
- Multiple enhancers ensure precision of gap gene-expression patterns in the Drosophila embryo.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Hairless is a cofactor for Runt-dependent transcriptional regulation.Molecular biology of the cell · 2011Article
- Long- and short-range transcriptional repressors induce distinct chromatin states on repressed genes.Current biology : CB · 2011Article
- EAR motif-mediated transcriptional repression in plants: an underlying mechanism for epigenetic regulation of gene expression.Epigenetics · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Groucho (Gro) is a Drosophila melanogaster transcriptional corepressor that directly interacts with the histone deacetylase Rpd3. Although previous studies suggest that this interaction is required for repression of Gro-responsive reporters in cultured cells, the in vivo significance of this interaction and the mechanism by which it leads to repression remain largely unexplored. In this study, we show that Gro is partially dependent on Rpd3 for repression, supporting the idea that Rpd3-mediated repression is one mode of Gro-mediated repression. We demonstrate that Gro colocalizes with Rpd3 to the chromatin of a target gene and that this is accompanied by the deacetylation of specific lysines within the N-terminal tails of histones H3 and H4. Gro overexpression leads to wing patterning defects and ectopic repression in the wing disc of transcription directed by the vestigial quadrant enhancer. These effects are reversed by the histone deacetylase inhibitors TSA and HC-Toxin and by the reduction of Rpd3 gene dosage. Furthermore, repression of the vestigial quadrant enhancer is accompanied by a Gro-mediated increase in nucleosome density, an effect that is reversed by histone deacetylase inhibitors. We propose a model in which Gro-mediated histone deacetylation results in increased nucleosome density leading to transcriptional repression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.