ArticleInternational journal of obesity (2005)2010
Sensitivity to the satiating effects of exendin 4 is decreased in obesity-prone Osborne-Mendel rats compared to obesity-resistant S5B/Pl rats.
Article in International journal of obesity (2005), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- Diet-induced obesity impairs refeeding responses and downregulates lateral septal GLP-1R in male rats: an effect reversed by weight-loss treatment.Frontiers in pharmacology · 2026Article
- Glucagon-Like Peptide-1 Links Ingestion, Homeostasis, and the Heart.Comprehensive Physiology · 2025Review
- Sex differences in markers of metabolic syndrome and adipose tissue inflammation in obesity-prone, Osborne-Mendel and obesity-resistant, S5B/Pl rats.Life sciences · 2021Article
- Transection of Gustatory Nerves Differentially Affects Dietary Fat Intake in Obesity-Prone and Obesity-Resistant Rats.Chemical senses · 2020Article
- High-fat diet alters fluid intake without reducing sensitivity to glucagon-like peptide-1 receptor agonist effects.Physiology & behavior · 2020Article
- Expression of neural markers of gustatory signaling are differentially altered by continuous and intermittent feeding patterns.Physiology & behavior · 2019Article
- The prevalence of cardio-metabolic risk factors is differentially elevated in obesity-prone Osborne-Mendel and obesity-resistant S5B/Pl rats.Life sciences · 2019Article
- High fat diet consumption differentially affects adipose tissue inflammation and adipocyte size in obesity-prone and obesity-resistant rats.International journal of obesity (2005) · 2018Article
- Lingual CD36 and nutritional status differentially regulate fat preference in obesity-prone and obesity-resistant rats.Physiology & behavior · 2017Article
- High-fat diet differentially regulates metabolic parameters in obesity-resistant S5B/Pl rats and obesity-prone Osborne-Mendel rats.Canadian journal of physiology and pharmacology · 2016Article
- Long term exendin-4 treatment reduces food intake and body weight and alters expression of brain homeostatic and reward markers.Endocrinology · 2014Article
- Nutrient-specific feeding and endocrine effects of jejunal infusions in obese animals.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Hypothalamic QRFP: regulation of food intake and fat selection.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2013Article
- Preference for linoleic acid in obesity-prone and obesity-resistant rats is attenuated by the reduction of CD36 on the tongue.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- CD36 mRNA in the gastrointestinal tract is differentially regulated by dietary fat intake in obesity-prone and obesity-resistant rats.Digestive diseases and sciences · 2013Article
- High fat diet differentially regulates the expression of olfactory receptors in the duodenum of obesity-prone and obesity-resistant rats.Digestive diseases and sciences · 2013Article
- Maintenance on a high-fat diet impairs the anorexic response to glucagon-like-peptide-1 receptor activation.Physiology & behavior · 2011Article
- GLP-1 and energy balance: an integrated model of short-term and long-term control.Nature reviews. Endocrinology · 2011Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundOsborne-Mendel (OM) rats are prone to obesity when fed a high-fat diet, whereas S5B/Pl (S5B) rats are resistant to diet-induced obesity when fed the same diet. OM rats have a decreased satiation response to fatty acids infused in the gastrointestinal tract, compared to S5B rats. One possible explanation is that OM rats are less sensitive to the satiating hormone, glucagon-like peptide 1 (GLP-1). GLP-1 is produced in the small intestine and is released in response to a meal. The current experiments examined the role of GLP-1 in OM and S5B rats.
methodsExperiment 1 examined preproglucagon mRNA expression in the ileum of OM and S5B rats fed a high-fat (55% kcal) or low-fat (10% kcal) diet. Experiment 2 investigated the effects of a 2 h high-fat meal after a 24 h fast in OM and S5B rats on circulating GLP-1 (active) levels. Experiment 3 examined the effects of exendin-4 (GLP-1 receptor agonist) administration on the intake of a high-fat or a low-fat diet in OM and S5B rats.
resultsPreproglucagon mRNA levels were increased in the ileum of OM rats compared to S5B rats and were increased by high-fat diet in OM and S5B rats. OM and S5B rats exhibited a similar meal-initiated increase in circulating GLP-1 (active) levels. Exendin-4 dose dependently decreased food intake to a greater extent in S5B rats compared to OM rats. The intake of low-fat diet, compared to the intake of high-fat diet, was more sensitive to the effects of exendin-4 in these strains.
conclusionsThese results suggest that though OM and S5B rats have similar preproglucagon mRNA expression in the ileum and circulating GLP-1 levels, OM rats are less sensitive to the satiating effects of GLP-1. Therefore, dysregulation of the GLP-1 system may be a mechanism through which OM rats overeat and gain weight.
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