ArticleHypertension (Dallas, Tex. : 1979)2010
Role of renal perfusion pressure versus angiotensin II on renal oxidative stress in angiotensin II-induced hypertensive rats.
Article in Hypertension (Dallas, Tex. : 1979), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- T-cells regulate albuminuria but not hypertension, renal histology, or the medullary transcriptome in the Dahl SSCD247American journal of physiology. Renal physiology · 2024Article
- Acute Increase of Renal Perfusion Pressure Causes Rapid Activation of mTORC1 (Mechanistic Target Of Rapamycin Complex 1) and Leukocyte Infiltration.Hypertension (Dallas, Tex. : 1979) · 2022Article
- Divergent roles of angiotensin II upon the immediate and sustained increases of renal blood flow following unilateral nephrectomy.American journal of physiology. Renal physiology · 2022Article
- Renal Perfusion Pressure Determines Infiltration of Leukocytes in the Kidney of Rats With Angiotensin II-Induced Hypertension.Hypertension (Dallas, Tex. : 1979) · 2020Article
- Renal denervation reduces sympathetic overactivation, brain oxidative stress, and renal injury in rats with renovascular hypertension independent of its effects on reducing blood pressure.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- Naringenin Ameliorates Renovascular Hypertensive Renal Damage by Normalizing the Balance of Renin-Angiotensin System Components in Rats.International journal of medical sciences · 2019Article
- Transcriptomic analysis reveals inflammatory and metabolic pathways that are regulated by renal perfusion pressure in the outer medulla of Dahl-S rats.Physiological genomics · 2018Article
- Hypertensive Kidney Injury and the Progression of Chronic Kidney Disease.Hypertension (Dallas, Tex. : 1979) · 2017Review
- The Renal Protective Effect of Jiangya Tongluo Formula, through Regulation of Adrenomedullin and Angiotensin II, in Rats with Hypertensive Nephrosclerosis.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- The role of reactive oxygen species in microvascular remodeling.International journal of molecular sciences · 2014Review
- Article
- Real-time electrochemical detection of ATP and H₂O₂ release in freshly isolated kidneys.American journal of physiology. Renal physiology · 2013Article
- Endothelin ET(B) receptors contribute to sex differences in blood pressure elevation in angiotensin II hypertensive rats on a high-salt diet.Clinical and experimental pharmacology & physiology · 2013Article
- Deficiency of renal cortical EGF increases ENaC activity and contributes to salt-sensitive hypertension.Journal of the American Society of Nephrology : JASN · 2013Article
- Involvement of cytochrome P-450 1B1 in renal dysfunction, injury, and inflammation associated with angiotensin II-induced hypertension in rats.American journal of physiology. Renal physiology · 2012Article
- Oxidative stress contributes to sex differences in angiotensin II-mediated hypertension in spontaneously hypertensive rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Article
- Chronic exercise preserves renal structure and hemodynamics in spontaneously hypertensive rats.Antioxidants & redox signaling · 2012Article
- Secreted klotho and chronic kidney disease.Advances in experimental medicine and biology · 2012Review
- Renal injury in angiotensin II+L-NAME-induced hypertensive rats is independent of elevated blood pressure.American journal of physiology. Renal physiology · 2011Article
- Intratubular renin-angiotensin system in hypertension.Hypertension (Dallas, Tex. : 1979) · 2011Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Renal oxidative stress is thought to contribute to both the etiology and the associated renal injury in angiotensin (Ang) II-dependent hypertension. The contribution of Ang II versus elevated renal perfusion pressure (RPP) on albuminuria and renal oxidative stress in this model of hypertension was explored in the present study by chronically servocontrolling RPP to the left kidney and comparing responses with the right uncontrolled kidney and the left kidney of sham rats. Hypertension was produced in Sprague-Dawley rats fed a 4% NaCl diet by chronic IV infusion of Ang II (25 ng/kg per minute). The RPP to the left kidney was servocontrolled to mean daily pressures averaging approximately 120 mm Hg, whereas the uncontrolled kidneys averaged approximately 170 mm Hg over 14 days of Ang II infusion. Ang II infusion resulted in a 2.4-fold increase in albuminuria, which was RPP dependent. Kidneys exposed to both elevated RPP and Ang II (uncontrolled kidneys) displayed a 3.5-fold increase in malondialdehyde excretion and a 37% and 27% increase in renal cortical and outer medullary superoxide production, respectively. Elevated RPP significantly contributed to global renal oxidative stress (70% increase in malondialdehyde excretion) and outer medullary superoxide production. Elevated circulating levels of Ang II, per se, were responsible for a 1.5-fold and 2.0-fold increase in renal cortical and outer medullary NADPH oxidase activity, respectively. In summary, this study demonstrates that elevated RPP is directly responsible for the excess albuminuria in Ang II-infused rats, whereas both elevated RPP and Ang II directly contribute to the observed renal oxidative stress.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.