ArticleProceedings of the National Academy of Sciences of the United States of America2010
In vivo magnetomotive optical molecular imaging using targeted magnetic nanoprobes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 125 citations in OpenAlex.
- Magnetically Controlled Reversible Photomagnetic Nanoactuators for Dynamic Contrast Enhancement in Optical Coherence Tomography.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Optical coherence tomography for noninvasive monitoring of drug delivery.Advanced drug delivery reviews · 2025Review
- Medical Imaging Technology for Micro/Nanorobots.Nanomaterials (Basel, Switzerland) · 2023Review
- Micro/Nanosystems for Magnetic Targeted Delivery of Bioagents.Pharmaceutics · 2022Review
- Design of Magnetic Nanoplatforms for Cancer Theranostics.Biosensors · 2022Review
- Magnetic particles in motion: magneto-motive imaging and sensing.Theranostics · 2022Review
- Spectral- and Polarization-Dependent Scattering of Gold Nanobipyramids for Exogenous Contrast in Optical Coherence Tomography.Nano letters · 2021Article
- Biomechanical sensing ofTheranostics · 2021Article
- Imaging methods to evaluate tumor microenvironment factors affecting nanoparticle drug delivery and antitumor response.Cancer drug resistance (Alhambra, Calif.) · 2021Article
- Biometric Measurement of Anterior Segment: A Review.Sensors (Basel, Switzerland) · 2020Review
- Inversion of displacement fields to quantify the magnetic particle distribution in homogeneous elastic media from magnetomotive ultrasound.Physics in medicine and biology · 2019Article
- Longitudinal elastic wave imaging using nanobomb optical coherence elastography.Optics letters · 2019Article
- Photothermal Optical Coherence Tomography of Anti-Angiogenic Treatment in the Mouse Retina Using Gold Nanorods as Contrast Agents.Translational vision science & technology · 2019Article
- Magnetomotive Displacement of the Tympanic Membrane Using Magnetic Nanoparticles: Toward Enhancement of Sound Perception.IEEE transactions on bio-medical engineering · 2018Article
- Nanobomb optical coherence elastography.Optics letters · 2018Article
- Effect of divalent ions and a polyphosphate on composition, structure, and stiffness of simulated drinking water biofilms.NPJ biofilms and microbiomes · 2018Article
- In vivo photothermal optical coherence tomography of endogenous and exogenous contrast agents in the eye.Scientific reports · 2017Article
- Combined Magnetomotive ultrasound, PET/CT, and MR imaging ofScientific reports · 2017Article
- In Vivo Molecular Optical Coherence Tomography of Lymphatic Vessel Endothelial Hyaluronan Receptors.Scientific reports · 2017Article
- Optical coherence elastography - OCT at work in tissue biomechanics [Invited].Biomedical optics express · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Dynamic magnetomotion of magnetic nanoparticles (MNPs) detected with magnetomotive optical coherence tomography (MM-OCT) represents a new methodology for contrast enhancement and therapeutic interventions in molecular imaging. In this study, we demonstrate in vivo imaging of dynamic functionalized iron oxide MNPs using MM-OCT in a preclinical mammary tumor model. Using targeted MNPs, in vivo MM-OCT images exhibit strong magnetomotive signals in mammary tumor, and no significant signals were measured from tumors of rats injected with nontargeted MNPs or saline. The results of in vivo MM-OCT are validated by MRI, ex vivo MM-OCT, Prussian blue staining of histological sections, and immunohistochemical analysis of excised tumors and internal organs. The MNPs are antibody functionalized to target the human epidermal growth factor receptor 2 (HER2 neu) protein. Fc-directed conjugation of the antibody to the MNPs aids in reducing uptake by macrophages in the reticulo-endothelial system, thereby increasing the circulation time in the blood. These engineered magnetic nanoprobes have multifunctional capabilities enabling them to be used as dynamic contrast agents in MM-OCT and MRI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.