ArticleProceedings of the National Academy of Sciences of the United States of America2010
Coupling a sensory hair-cell bundle to cyber clones enhances nonlinear amplification.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 46 citations in OpenAlex.
- Efferent control of hair cells mechanically coupled by artificial membranes.Scientific reports · 2025Article
- The Critical Thing about the Ear's Sensory Hair Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Dynamics of Mechanically Coupled Hair-Cell Bundles of the Inner Ear.Biophysical journal · 2021Article
- Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Active Biomechanics of Sensory Hair Bundles.Cold Spring Harbor perspectives in medicine · 2019Review
- High-order synchronization of hair cell bundles.Scientific reports · 2016Article
- From Biological Cilia to Artificial Flow Sensors: Biomimetic Soft Polymer Nanosensors with High Sensing Performance.Scientific reports · 2016Article
- Persistence, period and precision of autonomous cellular oscillators from the zebrafish segmentation clock.eLife · 2016Article
- Control of a hair bundle's mechanosensory function by its mechanical load.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Article
- Transduction channels' gating can control friction on vibrating hair-cell bundles in the ear.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Enhanced signal-to-noise ratios in frog hearing can be achieved through amplitude death.Journal of the Royal Society, Interface · 2013Article
- Phantom tones and suppressive masking by active nonlinear oscillation of the hair-cell bundle.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- A mean-field approach to elastically coupled hair bundles.The European physical journal. E, Soft matter · 2012Article
- Coupling and elastic loading affect the active response by the inner ear hair cell bundles.PloS one · 2012Article
- Spontaneous voltage oscillations and response dynamics of a Hodgkin-Huxley type model of sensory hair cells.Journal of mathematical neuroscience · 2011Article
- A differentially amplified motion in the ear for near-threshold sound detection.Nature neuroscience · 2011Article
- A critique of the critical cochlea: Hopf--a bifurcation--is better than none.Journal of neurophysiology · 2010Review
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The vertebrate ear benefits from nonlinear mechanical amplification to operate over a vast range of sound intensities. The amplificatory process is thought to emerge from active force production by sensory hair cells. The mechano-sensory hair bundle that protrudes from the apical surface of each hair cell can oscillate spontaneously and function as a frequency-selective, nonlinear amplifier. Intrinsic fluctuations, however, jostle the response of a single hair bundle to weak stimuli and seriously limit amplification. Most hair bundles are mechanically coupled by overlying gelatinous structures. Here, we assayed the effects of mechanical coupling on the hair-bundle amplifier by combining dynamic force clamp of a hair bundle from the bullfrog's saccule with real-time stochastic simulations of hair-bundle mechanics. This setup couples the hair bundle to two virtual hair bundles, called cyber clones, and mimics a situation in which the hair bundle is elastically linked to two neighbors with similar characteristics. We found that coupling increased the coherence of spontaneous hair-bundle oscillations. By effectively reducing noise, the synergic interplay between the hair bundle and its cyber clones also enhanced amplification of sinusoidal stimuli. All observed effects of coupling were in quantitative agreement with simulations. We argue that the auditory amplifier relies on hair-bundle cooperation to overcome intrinsic noise limitations and achieve high sensitivity and sharp frequency selectivity.
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