ArticleProceedings of the National Academy of Sciences of the United States of America2010
Uncoupling of growth plate maturation and bone formation in mice lacking both Schnurri-2 and Schnurri-3.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Effect of lyso-phosphatidylcholine and Schnurri-3 on osteogenic transdifferentiation of vascular smooth muscle cells to calcifying vascular cells in 3D culture.Biochimica et biophysica acta · 2013Trial
- Engineering a targeted and safe bone anabolic gene therapy to treat osteoporosis in alveolar bone loss.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Article
- Vertebrate-conserved Schnurri zinc fingers restrain Drosophila vein patterning.microPublication biology · 2024Article
- Review
- WNT-modulating gene silencers as a gene therapy for osteoporosis, bone fracture, and critical-sized bone defects.Molecular therapy : the journal of the American Society of Gene Therapy · 2023Article
- Bone-targeting AAV-mediated silencing of Schnurri-3 prevents bone loss in osteoporosis.Nature communications · 2019Article
- A catalog of single nucleotide changes distinguishing modern humans from archaic hominins.Scientific reports · 2019Article
- Inactivation of Nell-1 in Chondrocytes Significantly Impedes Appendicular Skeletogenesis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019Article
- Deletion of the PH-domain and Leucine-rich Repeat Protein Phosphatase 1 (Phlpp1) Increases Fibroblast Growth Factor (Fgf) 18 Expression and Promotes Chondrocyte Proliferation.The Journal of biological chemistry · 2015Article
- Human immunodeficiency virus type 1 enhancer-binding protein 3 is essential for the expression of asparagine-linked glycosylation 2 in the regulation of osteoblast and chondrocyte differentiation.The Journal of biological chemistry · 2014Article
- Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts.The Journal of clinical investigation · 2013Article
- Novel long noncoding RNAs are regulated by angiotensin II in vascular smooth muscle cells.Circulation research · 2013Article
- Site-1 protease is essential to growth plate maintenance and is a critical regulator of chondrocyte hypertrophic differentiation in postnatal mice.The Journal of biological chemistry · 2011Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Formation and remodeling of the skeleton relies on precise temporal and spatial regulation of genes expressed in cartilage and bone cells. Debilitating diseases of the skeletal system occur when mutations arise that disrupt these intricate genetic regulatory programs. Here, we report that mice bearing parallel null mutations in the adapter proteins Schnurri2 (Shn2) and Schnurri3 (Shn3) exhibit defects in patterning of the axial skeleton during embryogenesis. Postnatally, these compound mutant mice develop a unique osteochondrodysplasia. The deletion of Shn2 and Shn3 impairs growth plate maturation during endochondral ossification but simultaneously results in massively elevated trabecular bone formation. Hence, growth plate maturation and bone formation can be uncoupled under certain circumstances. These unexpected findings demonstrate that both unique and redundant functions reside in the Schnurri protein family that are required for proper skeletal patterning and remodeling.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.