ArticleInfection and immunity2010
Human brucellosis is characterized by an intense Th1 profile associated with a defective monocyte function.
Article in Infection and immunity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Association of the TNF-α-308, TNF-α-238 gene polymorphisms with risk of bone-joint and spinal tuberculosis: a meta-analysis.Bioscience reports · 2019Pooled it
- Meta-Analysis of the Changes of Peripheral Blood T Cell Subsets in Patients with Brucellosis.Journal of immunology research · 2018Pooled it
- The impact of previous brucellosis treatment on the clinical course of neurobrucellosis: a multicentre retrospective study.BMC infectious diseases · 2026Article
- Brucella abortus RNA does not polarize macrophages to a particular profile but interferes with M1 polarization.PLoS neglected tropical diseases · 2022Article
- Immunosuppressive Mechanisms in Brucellosis in Light of Chronic Bacterial Diseases.Microorganisms · 2022Review
- Key immunity characteristics of diverse stages of brucellosis in rural population from Inner Mongolia, China.Infectious diseases of poverty · 2022Article
- Live mucosal vaccination stimulates potent protectionFrontiers in immunology · 2022Article
- microRNAs in human brucellosis: A promising therapeutic approach and biomarker for diagnosis and treatment.Immunity, inflammation and disease · 2021Review
- Serum Levels of Seven General Cytokines in Acute Brucellosis Before and After Treatment.Infection and drug resistance · 2021Article
- Soluble IL-2Rα correlates with imbalances of Th1/Th2 and Tc1/Tc2 cells in patients with acute brucellosis.Infectious diseases of poverty · 2020Article
- Dynamic Changes of Th1 Cytokines and the Clinical Significance of the IFN-Mediators of inflammation · 2019Article
- Article
- Interferon-γ receptor-1 gene promoter polymorphisms and susceptibility for brucellosis in Makkah region.African health sciences · 2018Article
- An Autoimmune Disease-Associated Risk Variant in theJournal of clinical microbiology · 2018Article
- Article
- Chronic Bacterial Pathogens: Mechanisms of Persistence.Microbiology spectrum · 2016Review
- Ex vivo innate immune cytokine signature of enhanced risk of relapsing brucellosis.PLoS neglected tropical diseases · 2013Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In animal models, a defective Th1 response appears to be critical in the pathogenesis of brucellosis, but the Th1 response in human brucellosis patients remains partially undefined. Peripheral blood from 24 brucellosis patients was studied before and 45 days after antibiotherapy. Twenty-four sex- and age-matched healthy donors were analyzed in parallel. Significantly increased levels of interleukin 1beta (IL-1beta), IL-2, IL-4, IL-6, IL-12p40, gamma interferon (IFN-gamma), and tumor necrosis factor alpha (TNF-alpha), but not of IL-10, in serum and/or significantly increased percentages of samples with detectable levels of these cytokines, measured by enzyme-linked immunosorbent assays (ELISA), were found for untreated brucellosis patients, but these levels were reduced and/or normalized after treatment. Flow cytometry studies showed that the intracytoplasmic expression of IFN-gamma, IL-2, and TNF-alpha, but not that of IL-4, by phorbol myristate-activated CD4(+) CD3(+) and CD8(+) CD3(+) T lymphocytes was significantly increased in untreated brucellosis patients and was also partially normalized after antibiotherapy. The percentage of phagocytic cells, the mean phagocytic activity per cell, and the phagocytic indices for monocytes at baseline were defective and had only partially reverted at follow-up. T lymphocytes from untreated brucellosis patients are activated in vivo and show Th1 cytokine production polarization, with strikingly high serum IFN-gamma levels. In spite of this Th1 environment, we found deficient effector phagocytic activity in peripheral blood monocytes.
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