ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2010
Testicular postgenomics: targeting the regulation of spermatogenesis.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Emerging roles and therapeutic potential of tRNA-Derived small RNAs in reproductive system diseases: a review.Frontiers in cell and developmental biology · 2025Review
- Proteasome complexes experience profound structural and functional rearrangements throughout mammalian spermatogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Sperm Functional Genome Associated With Bull Fertility.Frontiers in veterinary science · 2021Review
- Filamentous actin disorganization and absence of apical ectoplasmic specialization disassembly during spermiation upon interference with retinoid signaling†.Biology of reproduction · 2020Article
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- The ReproGenomics Viewer: an integrative cross-species toolbox for the reproductive science community.Nucleic acids research · 2015Article
- Integrated transcriptome analysis of mouse spermatogenesis.BMC genomics · 2014Article
- An integrative omics strategy to assess the germ cell secretome and to decipher sertoli-germ cell crosstalk in the Mammalian testis.PloS one · 2014Article
- Differential proteomic profile of spermatogenic and Sertoli cells from peri-pubertal testes of three different bovine breeds.Frontiers in cell and developmental biology · 2014Article
- Bioinformatics for spermatogenesis: annotation of male reproduction based on proteomics.Asian journal of andrology · 2013Review
- Male-specific region of the bovine Y chromosome is gene rich with a high transcriptomic activity in testis development.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Expression analysis of MND1/GAJ, SPATA22, GAPDHS and ACR genes in testicular biopsies from non-obstructive azoospermia (NOA) patients.Reproductive biology and endocrinology : RB&E · 2013Article
- Sperm-related phenotypes implicated in both maintenance and breakdown of a natural species barrier in the house mouse.Proceedings. Biological sciences · 2012Article
- Novel insights into the downstream pathways and targets controlled by transcription factors CREM in the testis.PloS one · 2012Article
- Repertoire of porcine microRNAs in adult ovary and testis by deep sequencing.International journal of biological sciences · 2011Article
- Proteomics of spermatogenesis: from protein lists to understanding the regulation of male fertility and infertility.Asian journal of andrology · 2011Review
- Proteomics and the genetics of sperm chromatin condensation.Asian journal of andrology · 2011Review
- The biology of spermatogenesis: the past, present and future.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sperm are, arguably, the most differentiated cells produced within the body of any given species. This is owing to the fact that spermatogenesis is an intricate and highly specialized process evolved to suit the individual particularities of each sexual species. Despite a vast diversity in method, the aim of spermatogenesis is always the same, the idealized transmission of genetic patrimony. Towards this goal certain requirements must always be met, such as a relative twofold reduction in ploidy, repackaging of the chromatin for transport and specialized enhancements for cell motility, recognition and fusion. In the past 20 years, the study of molecular networks coordinating male germ cell development, particularly in mammals, has become more and more facilitated thanks to large-scale analyses of genome expression. Such postgenomic endeavors have generated landscapes of data for both fundamental and clinical reproductive biology. Continuous, large-scale integration analyses of these datasets are undertaken which provide access to very precise information on a myriad of biomolecules. This review presents commonly used transcriptomic and proteomic workflows applied to various testicular germ cell studies. We will also provide a general overview of the technical possibilities available to reproductive genomic biologists, noting the advantages and drawbacks of each technique.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.