ArticleNeuroImage2010
Cellular-level diffusion tensor microscopy and fiber tracking in mammalian nervous tissue with direct histological correlation.
Article in NeuroImage, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Considerations and recommendations from the ISMRM diffusion study group for preclinical diffusion MRI: Part 2-Ex vivo imaging: Added value and acquisition.Magnetic resonance in medicine · 2025Guideline
- A practical prescription for magnetic resonance microscopy in a horizontal bore magnet.Npj imaging · 2025Article
- Considerations and recommendations from the ISMRM Diffusion Study Group for preclinical diffusion MRI: Part 3-Ex vivo imaging: Data processing, comparisons with microscopy, and tractography.Magnetic resonance in medicine · 2025Review
- Enhanced spatial resolution in magnetic resonance imaging by dynamic nuclear polarization at 5 K.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Histopathological modeling of status epilepticus-induced brain damage based onFrontiers in neuroscience · 2022Article
- Neuroanatomical underpinning of diffusion kurtosis measurements in the cerebral cortex of healthy macaque brains.Magnetic resonance in medicine · 2021Article
- Visualization of live, mammalian neurons during Kainate-infusion using magnetic resonance microscopy.NeuroImage · 2020Article
- Diffusion Kurtosis Imaging as a Tool in Neurotoxicology.Neurotoxicity research · 2020Article
- Histological Correlates of Diffusion-Weighted Magnetic Resonance Microscopy in a Mouse Model of Mesial Temporal Lobe Epilepsy.Frontiers in neuroscience · 2020Article
- Retrieving neuronal orientations using 3D scanning SAXS and comparison with diffusion MRI.NeuroImage · 2020Article
- An Introduction to Kurtosis Fractional Anisotropy.AJNR. American journal of neuroradiology · 2019Review
- Article
- White matter biomarkers from fast protocols using axially symmetric diffusion kurtosis imaging.NMR in biomedicine · 2017Article
- Magnetic resonance imaging and computed tomography as tools for the investigation of sperm whale (Physeter macrocephalus) teeth and eye.Acta veterinaria Scandinavica · 2017Article
- Diffusion tensor microscopy data (15.6 μm in-plane) of white matter tracts in the human, pig, and rat spinal cord with corresponding tissue histology.Data in brief · 2016Article
- Fast imaging of mean, axial and radial diffusion kurtosis.NeuroImage · 2016Article
- Experimental considerations for fast kurtosis imaging.Magnetic resonance in medicine · 2016Article
- Kurtosis fractional anisotropy, its contrast and estimation by proxy.Scientific reports · 2016Article
- Diffusion MR Microscopy of Cortical Development in the Mouse Embryo.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Investigation of the subcellular architecture of L7 neurons of Aplysia californica using magnetic resonance microscopy (MRM) at 7.8 microns.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
7 authors.
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Abstract
Magnetic resonance imaging techniques have literally revolutionized neuroimaging with an unprecedented ability to explore tissue structure and function. Over the last three decades, the sensitivity and array of imaging techniques available have improved providing ever finer structural information and more sensitive functional techniques. Among these methods, diffusion imaging techniques have facilitated the generation of fiber-tract maps of the brain enabling an examination of issues related to brain structure and neural connectivity. Despite the potential utility of the techniques described, validation has not yet been achieved on biological samples. Recently, using newly developed surface microcoils on small samples at high magnetic fields, we demonstrated the ability of MR microscopy to image individual neurons in mammalian brain tissue. In the present work, we combine MR microscopy with the highest resolution (15microm) fiber tracking yet reported and demonstrate the accuracy of the fiber tract maps with direct histological validation. Thus it becomes possible to delineate fiber structure in tissues at the cellular level. A semi-quantitative approach was used to estimate the cell overlap fraction (cOF) and fiber tract overlap fraction (tOF), with cOFs of 94%, 92% and 100%, and tOFs of 84%, 86% and 100%, in rat cervical, rat lumbar, and pig spinal cord tissue, respectively. These methods provide a way to directly validate fiber tracking techniques with histology so that contemporary tracking techniques may be compared and refined using the microstructural details of a biological template as a ground truth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.