ArticleBMC genomics2010
Comparative gene expression in toxic versus non-toxic strains of the marine dinoflagellate Alexandrium minutum.
Article in BMC genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 82 citations in OpenAlex.
- Redescription and neotypification of Alexandrium minutum Halim-the type species of Alexandrium-from its type locality in Alexandria, Egypt, with insights into ribotype biogeography and toxicity.Journal of phycology · 2026Article
- Molecular Mechanisms of Algicidal Bacteria in Controlling Harmful Algal Blooms: Advances in Bacteria-Algae Interactions.Environmental microbiology reports · 2026Review
- Review
- Biochemical Mapping ofInternational journal of molecular sciences · 2021Article
- Molecular Identification and Toxin Analysis ofToxins · 2021Article
- From theFrontiers in microbiology · 2021Article
- Differentiating Two Closely RelatedToxins · 2020Article
- Biosynthesis of Saxitoxin in Marine Dinoflagellates: An Omics Perspective.Marine drugs · 2020Review
- Omics Analysis for Dinoflagellates Biology Research.Microorganisms · 2019Review
- The Genetic Basis of Toxin Biosynthesis in Dinoflagellates.Microorganisms · 2019Review
- Distinctive Nuclear Features of Dinoflagellates with A Particular Focus on Histone and Histone-Replacement Proteins.Microorganisms · 2018Review
- Core genes in diverse dinoflagellate lineages include a wealth of conserved dark genes with unknown functions.Scientific reports · 2018Article
- Transcriptomic Analyses ofFrontiers in microbiology · 2017Article
- Review
- Gene Expression Variation Resolves Species and Individual Strains among Coral-Associated Dinoflagellates within the Genus Symbiodinium.Genome biology and evolution · 2016Article
- Transcriptome Analysis of Scrippsiella trochoidea CCMP 3099 Reveals Physiological Changes Related to Nitrate Depletion.Frontiers in microbiology · 2016Article
- Induction of reactive oxygen species in marine phytoplankton under crude oil exposure.Environmental science and pollution research international · 2015Article
- The alveolate translation initiation factor 4E family reveals a custom toolkit for translational control in core dinoflagellates.BMC evolutionary biology · 2015Article
- Transcriptomic characterisation and genomic glimps into the toxigenic dinoflagellate Azadinium spinosum, with emphasis on polykeitde synthase genes.BMC genomics · 2015Article
- Paralytic shellfish toxin content is related to genomic sxtA4 copy number in Alexandrium minutum strains.Frontiers in microbiology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe dinoflagellate Alexandrium minutum typically produces paralytic shellfish poisoning (PSP) toxins, which are known only from cyanobacteria and dinoflagellates. While a PSP toxin gene cluster has recently been characterized in cyanobacteria, the genetic background of PSP toxin production in dinoflagellates remains elusive.
resultsWe constructed and analysed an expressed sequence tag (EST) library of A. minutum, which contained 15,703 read sequences yielding a total of 4,320 unique expressed clusters. Of these clusters, 72% combined the forward-and reverse reads of at least one bacterial clone. This sequence resource was then used to construct an oligonucleotide microarray. We analysed the expression of all clusters in three different strains. While the cyanobacterial PSP toxin genes were not found among the A. minutum sequences, 192 genes were differentially expressed between toxic and non-toxic strains.
conclusionsBased on this study and on the lack of identified PSP synthesis genes in the two existent Alexandrium tamarense EST libraries, we propose that the PSP toxin genes in dinoflagellates might be more different from their cyanobacterial counterparts than would be expected in the case of a recent gene transfer. As a starting point to identify possible PSP toxin-associated genes in dinoflagellates without relying on a priori sequence information, the sequences only present in mRNA pools of the toxic strain can be seen as putative candidates involved in toxin synthesis and regulation, or acclimation to intracellular PSP toxins.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.